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Increased serum levels of macrophage migration inhibitory factor in patients with Kawasaki disease

Authors
 T. J. Lee  ;  J. K. Chun  ;  D. S. Kim  ;  J. S. Shin  ;  S. I. Yeon 
Citation
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.36(3) : 222-225, 2007 
Journal Title
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 
ISSN
 0300-9742 
Issue Date
2007
Abstract
OBJECTIVE: To determine whether serum levels of macrophage migration inhibitory factor (MIF) increase in patients with Kawasaki disease (KD) and also correlate with other inflammatory indices. METHODS: Serum samples from 10 patients with KD, 15 normal healthy subjects, and seven febrile control subjects were assayed for MIF by enzyme-linked immunosorbent assay (ELISA). RESULTS: There was a significant increase in the serum levels of MIF in the acute stage of KD [113.06 (range 20.6-157.36) ng/mL] compared with those in the subacute stage [28.11 (8.57-143.48) ng/mL, p<0.01], normal controls [12.95 (8.40-18.67) ng/mL, p<0.001], and febrile controls [36.58 (21.31-59.67) ng/mL, p = 0.01]. The increase in MIF correlated with an increase in interleukin-6 (IL-6) (r = 0.52, p = 0.047). CONCLUSION: MIF may be a useful marker in the acute stage of KD and may provide important clues to the pathogenesis of this disease.
Full Text
http://informahealthcare.com/doi/abs/10.1080/03009740701218790
DOI
10.1080/03009740701218790
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
Lee, Taek Jin(이택진)
Chun, Jin Kyong(전진경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97351
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