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White matter abnormalities associated with auditory hallucinations in schizophrenia: A combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging

Authors
 Jeong-Ho Seok  ;  Hae-Jeong Park  ;  Jae-Jin Kim  ;  Jun Soo Kwon  ;  Hyun Sang Cho  ;  Seung-Koo Lee  ;  Ji-Won Chun 
Citation
 PSYCHIATRY RESEARCH, Vol.156(2) : 93-104, 2007 
Journal Title
 PSYCHIATRY RESEARCH 
ISSN
 0165-1781 
Issue Date
2007
Abstract
White matter (WM) abnormalities in schizophrenia may offer important clues to a better understanding of the disconnectivity associated with the disorder. The aim of this study was to elucidate a WM basis of auditory hallucinations in schizophrenia through the simultaneous investigation of WM tract integrity and WM density. Diffusion tensor images (DTIs) and structural T1 magnetic resonance images (MRIs) were taken from 15 hallucinating schizophrenic patients, 15 non-hallucinating schizophrenic patients and 22 normal controls. Voxel-based analyses and post-hoc region of interest analyses were obtained to compare the three groups on fractional anisotropy (FA) derived from DTI as well as WM density derived from structural MRIs. In both the hallucinating and non-hallucinating groups, FA of the WM regions was significantly decreased in the left superior longitudinal fasciculus (SLF), whereas WM density was significantly increased in the left inferior longitudinal fasciculus (ILF). The mean FA value of the left frontal part of the SLF was positively correlated with the severity score of auditory hallucinations in the hallucinating patient group. Our findings show that WM changes were mainly observed in the frontal and temporal areas, suggesting that disconnectivity in the left fronto–temporal area may contribute to the pathophysiology of schizophrenia. In addition, pathologic WM changes in this region may be an important step in the development of auditory hallucinations in schizophrenia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0925492707000364
DOI
10.1016/j.pscychresns.2007.02.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Cho, Hyun Sang(조현상) ORCID logo https://orcid.org/0000-0003-1019-9941
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97326
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