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Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer

 Yoon Soo Chang  ;  Hyung Jung Kim  ;  Se Kyu Kim  ;  Sung Kyu Kim  ;  Chul Min Ahn  ;  Joon Chang 
 Lung Cancer, Vol.57(3) : 373-380, 2007 
Journal Title
 Lung Cancer 
Issue Date
Osteopontin (OPN) plays important roles in tumor progression and metastasis through binding to OPN receptors such as αvββ integrin and CD44, and its overexpression in tumor is associated poor clinical outcome of NSCLC patients. Circulating OPN levels, measured by ELISA in 130 NSCLC cases that had not been treated for cancer at the time of sampling, were analyzed according to clinical, pathologic parameters and single nucleotide polymorphisms (SNPs) in the OPN gene promoter. Advanced disease states had higher circulating levels of OPN (T4 versus T1–3, N3 versus N0–2, and M1 versus M0, P = .029, .001, and .001, respectively, Kruskal–Wallis H-test), reflected by higher level of OPN in stage IV than stage I–III (P = .029, Kruskal–Wallis H-test). Among the clinical and pathological parameters including age, gender, smoking status, histologic subtypes and grade of differentiation, smoking status influences circulating OPN level showing higher level of OPN in ex-smokers than current and non-smokers (P = .038, Kruskal–Wallis H-test). Variation at nucleotide (nt) −443 of the OPN gene promoter had no influence on circulating OPN levels, however, patients with G/G at nt −156 showed higher concentrations of OPN than those with G/GG or GG/GG (P = .003, Kruskal–Wallis H-test). A patient with G/G at nt −156 was more frequently diagnosed with advanced stage (IIIB–IV) than with early stage (I–IIIA) NSCLC (P = .048, Mantel–Haenszel-test). In multivariate analysis, stage is the only independent factor influencing circulating level of OPN. Although circulating level of OPN in the patients with bone metastasis was higher than in those without bone metastasis (P = .028, Mann–Whitney U-test), there was no difference in the OPN levels between bone metastasis group and non-bone metastasis group. Given that the elevated levels of OPN is associated with advanced stages of NSCLC, elucidating OPN regulatory mechanisms may contribute to the development of a new therapeutic modality for NSCLC.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김성규(Kim, Sung Kyu)
김세규(Kim, Se Kyu)
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
안철민(Ahn, Chul Min)
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
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