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깨어있는 기니 픽의 위, 회장, 대장 운동에 대한 Mosapride Citrate의 효과

Other Titles
 Effects of Mosapride Citrate on the Motility of Stomach, Ileum and Colon in Conscious Guinea Pigs 
Authors
 박찬익  ;  정인수  ;  박효진  ;  김혜영  ;  김남규  ;  임정현 
Citation
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지), Vol.13(1) : 53-60, 2007 
Journal Title
Korean Journal of Neurogastroenterology and Motility(대한소화관운동학회지)
ISSN
 2093-0879 
Issue Date
2007
Abstract
Background/Aims: Mosapride citrate (Mosapride) is a relatively new selective 5-HT4 receptor agonist. Several studies have reported that mosapride selectively stimulates the upper GI motility, but not lower GI motility. However, 5-HT4 receptors are distributed in the stomach, small bowel and colon as well. In other studies, mosapride had a stimulatory effect on the lower GI tract. Therefore, we studied the effects of mosapride on the upper (stomach) and lower GI tract (ileum, proximal colon and distal colon) in conscious guinea pigs. Methods: We implanted force transducers into guinea pig`s stomach, ileum, proximal colon and distal colon. Mosapride (0, 1, 3, 10 and 30 mg/kg) was administered intragastrically through a polyethylene tube. The GI motor activity was measured by the motor index. After mosapride 10 mg/kg was administered intragastrically, atropine sulfate or GR113808 was administered intravenously. Results: Mosapride significantly stimulated the motor activities of the stomach, ileum and colon. The relative prokinetic potency of mosapride was not different among the 4 sites of the GI tract. The enhancing effect of mosapride was antagonized by atropine or GR113808, a selective 5-HT4 receptor antagonist. Conclusions: This study indicates that mosapride enhances both the upper and lower GI motility with similar potency by stimulation of the 5-HT4 receptor that is mediated by cholinergic neurons in a conscious guinea pig. Based on the possibility of obtaining similar results in humans, we suggest that mosapride may be useful for the treatment of upper and lower GI motor disorders.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Hye Young(김혜영)
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Jung, In Su(정인수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96981
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