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Podocyte biology in diabetic nephropathy

 J J Li  ;  S J Kwak  ;  S-W Kang  ;  D S Han  ;  D K Kim  ;  S J Moon  ;  J E Lee  ;  H Y Choi  ;  S H Han  ;  D-R Ryu  ;  T-H Yoo  ;  J-J Kim  ;  D S Jung 
 KIDNEY INTERNATIONAL, Vol.72(Suppl) : 36-42, 2007 
Journal Title
Issue Date
Glomerular visceral epithelial cells, namely podocytes, are highly specialized cells and give rise to primary processes, secondary processes, and finally foot processes. The foot processes of neighboring podocytes interdigitate, leaving between them filtration slits. These are bridged by an extracellular substance, known as the slit diaphragm, which plays a major role in establishing size-selective barrier to protein loss. Furthermore, podocytes are known to synthesize matrix molecules to the glomerular basement membrane (GBM), including type IV collagen, laminin, entactin, and agrin. Because diabetic nephropathy is clinically characterized by proteinuria and pathologically by glomerular hypertrophy and GBM thickening with foot process effacement, podocytes have been the focus in the field of research on diabetic nephropathy. As a result, many investigations have demonstrated that the diabetic milieu per se, hemodynamic changes, and local growth factors such as transforming growth factor-beta and angiotensin II, which are considered mediators in the pathogenesis of diabetic nephropathy, induce directly and/or indirectly hypertrophy, apoptosis, and structural changes, and increase type IV collagen synthesis in podocytes. This review explores some of the structural and functional changes of podocytes under diabetic conditions and their role in the development and progression of diabetic nephropathy.
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1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kwak, Seung Jae(곽승재)
Kim, Dong Ki(김동기)
Kim, Jin Ju(김진주)
Moon, Sung Jin(문성진)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Li, Jin Ji(이금희)
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Jung, Dong Sub(정동섭)
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
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