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The Effects of Antibiotics Blended Chitosan Membranes on the Calvarial Critical Size Defect in Sprague Dawely Rats

 Gyung Joon Chae  ;  Sang Bae Lee  ;  Seong Ho Choi  ;  Chong Kwan Kim  ;  Yong Keun Lee  ;  Ui Won Jung 
 Key Engineering Materials, Vol.342~343 : 857-860, 2007 
Journal Title
 Key Engineering Materials 
Issue Date
The purpose of this study was to evaluate the osteogenesis of tetracycline blended chitosan membranes on the calvarial critical size defect in Sprague Dawley. An 8 mm surgical defect was created with a trephine bur in the area of the midsagittal suture. Forty rats were divided into four groups: negative control group, positive control group and two experimental groups. Three types of membranes were made and a comparative study was done. One type of non-woven membrane was made by chitosan for positive control. The other two types of non-woven membranes were made by immersing non-woven chitosan into either the tetracycline solution or the chitosan-tetracycline solution. Histologic analysis was done at 2 weeks and 8 weeks of healing periods. We concluded that that the use of tetracycline blended chitosan membrane on the calvarial defects in rats has a significant effect on the regeneration of bone tissue in itself. In addition it implicates that tetracycline blended chitosan membrane may be useful for guided tissue regeneration.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Lee, Yong Keun(이용근)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Chae, Gyung Joon(채경준)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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