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Mycobacterium tuberculosis Derived Epitope Peptide Specific CD8+ T Cell Response in Tuberculous Pleurisy

 Jang-Eun Cho  ;  Young Sam Kim  ;  Sungae Cho  ;  Sang-Nae Cho  ;  Eunhee Lee  ;  Kyung Wha Lee  ;  Moo Suk Park 
 Journal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.13(4) : 325-332, 2007 
Journal Title
 Journal of Experimental & Biomedcal Science (대한의생명과학회지) 
Issue Date
Cell-mediated immune response (CMI) is a major immune protective mechanism against tuberculosis (TB) infection. Among several components involved in CMI, recent studies suggest that CD8+ T cells are important in controlling TB infection. In our previous report, we defined four Mycobacterium tuberculosis (MTB) derived epiotpe peptides specific for HLA-A*0201-restricted CD8+ T cells. These four peptides are PstA175-83, ThyA30-38, RpoB127-135 and 85B15-23. In this study, these epitope peptides specific CD8+ T cell responses in tuberculous pleurisy were investigated using ex vivo IFN-γ elispot assay and intracellular IFN-γ staining method. As a result, we observed these epitope peptide specific CD8+ T cell responses are induced in all three patients with tuberculous pleurisy suggesting that CD8+ T cells are involved in protective immune mechanism against MTB infection in tuberculous pleurisy. However, the CMI to mitogens and MTB antigens from pleural fluids of patients with tuberculous pleurisy does not seem to correlate with that from peripheral blood, although the sample size is too small to make any conclusion. In sum, the MHC I restricted CD8+ T cell responses seem to be induced efficiently in the pleural fluids, at the site of TB infection, in which the CMI is actively induced. In addition, these experiments suggest that MHC I restricted CD8+ T cell mediated immune responses are also involved in protective mechanism against MTB infection in extra-pulmonary TB.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Cho, Sang Nae(조상래)
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