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Mycobacterium tuberculosis Derived Epitope Peptide Specific CD8+ T Cell Response in Tuberculous Pleurisy
DC Field | Value | Language |
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dc.contributor.author | 김영삼 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2014-12-21T16:46:38Z | - |
dc.date.available | 2014-12-21T16:46:38Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1738-3226 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96330 | - |
dc.description.abstract | Cell-mediated immune response (CMI) is a major immune protective mechanism against tuberculosis (TB) infection. Among several components involved in CMI, recent studies suggest that CD8+ T cells are important in controlling TB infection. In our previous report, we defined four Mycobacterium tuberculosis (MTB) derived epiotpe peptides specific for HLA-A*0201-restricted CD8+ T cells. These four peptides are PstA175-83, ThyA30-38, RpoB127-135 and 85B15-23. In this study, these epitope peptides specific CD8+ T cell responses in tuberculous pleurisy were investigated using ex vivo IFN-γ elispot assay and intracellular IFN-γ staining method. As a result, we observed these epitope peptide specific CD8+ T cell responses are induced in all three patients with tuberculous pleurisy suggesting that CD8+ T cells are involved in protective immune mechanism against MTB infection in tuberculous pleurisy. However, the CMI to mitogens and MTB antigens from pleural fluids of patients with tuberculous pleurisy does not seem to correlate with that from peripheral blood, although the sample size is too small to make any conclusion. In sum, the MHC I restricted CD8+ T cell responses seem to be induced efficiently in the pleural fluids, at the site of TB infection, in which the CMI is actively induced. In addition, these experiments suggest that MHC I restricted CD8+ T cell mediated immune responses are also involved in protective mechanism against MTB infection in extra-pulmonary TB. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 325~332 | - |
dc.relation.isPartOf | Journal of Experimental & Biomedcal Science (대한의생명과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Mycobacterium tuberculosis Derived Epitope Peptide Specific CD8+ T Cell Response in Tuberculous Pleurisy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jang-Eun Cho | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Sungae Cho | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Eunhee Lee | - |
dc.contributor.googleauthor | Kyung Wha Lee | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J01408 | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 332 | - |
dc.identifier.bibliographicCitation | Journal of Experimental & Biomedcal Science (대한의생명과학회지), Vol.13(4) : 325-332, 2007 | - |
dc.identifier.rimsid | 37017 | - |
dc.type.rims | ART | - |
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