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Recurrence patterns of combined hepatocellular-cholangiocarcinoma on enhanced computed tomography

Authors
 Cheong-Il Shin  ;  Jeong Min Lee  ;  Se Hyung Kim  ;  Jin Young Choi  ;  Jae Young Lee  ;  Joon Koo Han  ;  Soo Yeon Jo  ;  Byung Ihn Choi 
Citation
 JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, Vol.31(1) : 109-115, 2007 
Journal Title
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
ISSN
 0363-8715 
Issue Date
2007
MeSH
Adult ; Aged ; Bile Duct Neoplasms/diagnostic imaging* ; Bile Ducts, Intrahepatic* ; Carcinoma, Hepatocellular/diagnostic imaging* ; Cholangiocarcinoma/diagnostic imaging* ; Female ; Humans ; Liver Neoplasms/diagnostic imaging* ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging* ; Neoplasms, Multiple Primary/diagnostic imaging* ; Radiographic Image Enhancement ; Retrospective Studies ; Tomography, X-Ray Computed*/methods
Abstract
OBJECTIVE:
To determine whether the computed tomographic (CT) findings of primary and recurrent combined hepatocellular-cholangiocarcinoma (HCC-CC) can predict the main tumor component on histopathologic examination, and to describe the recurrence patterns of HCC-CC after surgery.
METHODS:
Preoperative and postoperative CT findings of 12 HCC-CC patients who underwent curative surgery were retrospectively reviewed. The main features of the primary and recurrent tumors on CT and the pathological findings were classified as hepatocellular carcinoma (HCC)-dominant and cholangiocarcinoma (CC)-dominant groups. The concordance between the preoperative CT features and the initial pathological findings was evaluated using kappa statistics. The survival periods of the HCC-dominant and the CC-dominant group were compared using the Mann-Whitney U test.
RESULTS:
In 11 (91.7%) of 12 patients, the main CT features of HCC-CC were in strong agreement with main pathological findings (kappa = 0.824). The most common site of recurrence was the remnant liver. In 3 cases, only nodal metastasis was noted. The mean survival period was significantly longer in the HCC-dominant group than in the CC-dominant group of recurrent tumor (P = 0.016).
CONCLUSIONS:
Contrast-enhanced CT scanning can predict the dominant component of primary and recurrent HCC-CC. This capability can optimize treatment strategy for the patient with recurrent HCC-CC.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004728-200701000-00018&LSLINK=80&D=ovft
DOI
10.1097/01.rct.0000235072.34808.9b
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96278
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