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Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type

Authors
 Su Jung Shim  ;  Woo-Ick Yang  ;  Gwi Eon Kim  ;  Joo Hang Kim  ;  Chang Ok Suh  ;  Jae Ho Cho  ;  Yong Bae Kim  ;  Woong Sub Koom  ;  Eunah Shin 
Citation
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.67(1) : 31-38, 2007 
Journal Title
 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 
ISSN
 0360-3016 
Issue Date
2007
MeSH
Adolescent ; Adult ; Aged ; Cyclooxygenase 2/metabolism* ; Disease-Free Survival ; Female ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/metabolism* ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/radiotherapy ; Humans ; Lymphoma, T-Cell/drug therapy ; Lymphoma, T-Cell/metabolism* ; Lymphoma, T-Cell/mortality ; Lymphoma, T-Cell/radiotherapy ; Male ; Middle Aged ; Neoplasm Proteins/metabolism* ; Nose Neoplasms/drug therapy ; Nose Neoplasms/metabolism ; Nose Neoplasms/radiotherapy ; Prognosis ; Recurrence ; Remission Induction ; Retrospective Studies ; Treatment Outcome
Keywords
Natural Killer/T-cell lymphoma ; COX-2 ; Systemic recurrence
Abstract
PURPOSE: To determine whether there are any differences in therapeutic response, patterns of systemic recurrence, and prognosis of patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type, by the cyclooxygenase-2 (COX-2) expression. PATIENTS AND METHODS: Thirty-four patients with Ann Arbor Stage I and II extranodal NK/T-cell lymphoma who underwent chemotherapy or radiotherapy, or both, were retrospectively reviewed. These patients were divided into two groups according to their immunohistochemical staining for COX-2 expressions: a COX-2-negative group (n = 10 patients) and a COX-2-positive group (n = 24 patients). The treatment response, patterns of treatment failure, and survival data for the patients were compared between the COX-2-positive and negative groups. RESULTS: There was no significant difference in the clinical profiles between the COX-2-negative and COX-2-positive groups. All patients (100%) in the COX-2-negative group achieved complete response after initial treatment, whereas only 14 patients (58%) in the COX-2-positive group achieved complete response (p = 0.03). Compared with the patients in the COX-2-negative group, those in the COX-2-positive group had a significantly lower 2-year systemic recurrence-free survival rate (100% for the COX-2-negative group vs. 54% for the COX-2-positive group) (p = 0.02) and a decreased 5-year overall survival rate (70% for the COX-2-negative group vs. 32% for the COX-2-positive group) (p = 0.06). CONCLUSION: Cyclooxygenase-2 expression can serve as a predictive factor for poor treatment response, higher systemic recurrence, and unfavorable prognosis in patients with extranodal NK/T-cell lymphoma, nasal type.
Full Text
http://www.sciencedirect.com/science/article/pii/S0360301606027763
DOI
10.1016/j.ijrobp.2006.07.1387
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Gwi Eon(김귀언)
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Kim, Joo Hang(김주항)
Suh, Chang Ok(서창옥)
Shim, Su Jung(심수정)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96189
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