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Visualization of maturation of the corpus callosum during childhood and adolescence using T2 relaxometry

Authors
 Eung Y. Kim  ;  Dong-Hyun Kim  ;  Dong I. Kim  ;  Jinna Kim  ;  Dong J. Kim  ;  Seung-Koo Lee  ;  Xavier Golay  ;  Hae-Jeong Park  ;  Eunhye Yoo 
Citation
 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, Vol.25(6) : 409-414, 2007 
Journal Title
 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 
ISSN
 0736-5748 
Issue Date
2007
MeSH
Adolescent ; Adult ; Aging/physiology* ; Anthropometry/methods ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/growth & development* ; Child ; Child, Preschool ; Corpus Callosum/anatomy & histology ; Corpus Callosum/growth & development* ; Female ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Nerve Fibers, Myelinated/physiology ; Neural Pathways/anatomy & histology ; Neural Pathways/growth & development ; Retrospective Studies ; Sex Characteristics
Keywords
Human development ; Corpus callosum ; Magnetic resonance imaging
Abstract
Previous studies have shown that maturation of the white matter in terms of its relative signal intensity changes on MRI is almost complete at 2–3 years of age. We hypothesized that quantitative analysis may show maturation of the white matter during childhood and adolescence. In the present study we performed multi-echo T2 relaxometry in 33 healthy subjects (girls, 15; boys, 18) aged 3–15 years. T2 relaxation times of the genu and splenium were measured. In healthy subjects, the T2 relaxation times were significantly correlated with age in both girls (r = 0.611, p = .016) and boys (r = 0.721, p = .001) in the splenium, but not in the genu (p > .05). To further confirm genu-to-splenium signal intensity ratio changes, a total of 389 brain MRIs were retrospectively selected from the patients who had normal results (189 girls/women, 200 boys/men; age range, 3–20 years). The genu-to-splenium signal intensity ratio was obtained from the T2-weighted images. In patients with normal MRI, the genu-to-splenium signal intensity ratio was significantly decreased with age (p < .001) by 16 years. The T2 relaxation times gradually increase in the splenium during childhood and adolescence, suggestive of maturation.
Full Text
http://www.sciencedirect.com/science/article/pii/S0736574807000743
DOI
10.1016/j.ijdevneu.2007.05.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Eung Yeop(김응엽)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Yoo, Eun Hye(유은혜)
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96158
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