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Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C

Authors
 Yong-Joon Chwae  ;  Jae Myun Lee  ;  Jongsun Kim  ;  Jae-Won Soh  ;  Seung Tae Lee  ;  Eun Joon Kim 
Citation
 Immunology and Cell Biology, Vol.85(3) : 220-228, 2007 
Journal Title
 Immunology and Cell Biology 
ISSN
 0818-9641 
Issue Date
2007
Abstract
Inhibitory killer Ig-like receptor (KIR) expression was upregulated by protein kinase C (PKC) activation in stable Jurkat clones that express KIR or CD8KIR fusion proteins. PKC-induced KIR upregulation was mediated by the cytoplasmic tail of KIR and regulated at the post-transcriptional level. PKC inhibition, metabolic labeling and colocalization studies demonstrated that the activation of the conventional PKCs upregulated surface and cellular KIR levels by stimulating the maturation processes in endoplasmic reticulum-Golgi and by promoting the recycling of surface KIR through sorting endosomes. Similar studies also revealed that KIR was secreted to plasma membrane through lytic granules in a PKCdelta-dependent manner. Consequently, PKCdelta inhibition caused the formation of giant perinuclear granules, which trapped KIR and FasL as well as CPE and Lamp1.
Full Text
http://www.nature.com/icb/journal/v85/n3/full/7100031a.html
DOI
10.1038/sj.icb.7100031
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김종선(Kim, Jong Sun) ORCID logo https://orcid.org/0000-0002-3149-669X
이승태(Lee, Seung Tae)
이재면(Lee, Jae Myun) ORCID logo https://orcid.org/0000-0002-5273-3113
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96111
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