Cited 7 times in
Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C
DC Field | Value | Language |
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dc.contributor.author | 김종선 | - |
dc.contributor.author | 이승태 | - |
dc.contributor.author | 이재면 | - |
dc.date.accessioned | 2014-12-21T16:39:43Z | - |
dc.date.available | 2014-12-21T16:39:43Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0818-9641 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96111 | - |
dc.description.abstract | Inhibitory killer Ig-like receptor (KIR) expression was upregulated by protein kinase C (PKC) activation in stable Jurkat clones that express KIR or CD8KIR fusion proteins. PKC-induced KIR upregulation was mediated by the cytoplasmic tail of KIR and regulated at the post-transcriptional level. PKC inhibition, metabolic labeling and colocalization studies demonstrated that the activation of the conventional PKCs upregulated surface and cellular KIR levels by stimulating the maturation processes in endoplasmic reticulum-Golgi and by promoting the recycling of surface KIR through sorting endosomes. Similar studies also revealed that KIR was secreted to plasma membrane through lytic granules in a PKCdelta-dependent manner. Consequently, PKCdelta inhibition caused the formation of giant perinuclear granules, which trapped KIR and FasL as well as CPE and Lamp1. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 220~228 | - |
dc.relation.isPartOf | IMMUNOLOGY AND CELL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetophenones/pharmacology | - |
dc.subject.MESH | Arthritis, Rheumatoid/immunology | - |
dc.subject.MESH | Benzopyrans/pharmacology | - |
dc.subject.MESH | Carbazoles/pharmacology | - |
dc.subject.MESH | Endoplasmic Reticulum/metabolism | - |
dc.subject.MESH | Endosomes/metabolism | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Exocytosis | - |
dc.subject.MESH | Gene Expression Regulation*/drug effects | - |
dc.subject.MESH | Golgi Apparatus/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Indoles/pharmacology | - |
dc.subject.MESH | Jurkat Cells | - |
dc.subject.MESH | Lysosomes/metabolism | - |
dc.subject.MESH | Protein Isoforms/metabolism | - |
dc.subject.MESH | Protein Kinase C/antagonists & inhibitors | - |
dc.subject.MESH | Protein Kinase C/metabolism* | - |
dc.subject.MESH | Protein Kinase C-delta/metabolism* | - |
dc.subject.MESH | Protein Transport | - |
dc.subject.MESH | Receptors, Immunologic/metabolism* | - |
dc.subject.MESH | Receptors, KIR | - |
dc.subject.MESH | Recombinant Fusion Proteins/metabolism | - |
dc.subject.MESH | T-Lymphocytes/metabolism* | - |
dc.subject.MESH | Tetradecanoylphorbol Acetate/pharmacology | - |
dc.subject.MESH | Up-Regulation | - |
dc.title | Activation-induced upregulation of inhibitory killer Ig-like receptors is regulated by protein kinase C | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Yong-Joon Chwae | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Jongsun Kim | - |
dc.contributor.googleauthor | Jae-Won Soh | - |
dc.contributor.googleauthor | Seung Tae Lee | - |
dc.contributor.googleauthor | Eun Joon Kim | - |
dc.identifier.doi | 10.1038/sj.icb.7100031 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00921 | - |
dc.contributor.localId | A02930 | - |
dc.contributor.localId | A03071 | - |
dc.relation.journalcode | J01037 | - |
dc.identifier.eissn | 1440-1711 | - |
dc.identifier.pmid | 17228322 | - |
dc.identifier.url | http://www.nature.com/icb/journal/v85/n3/full/7100031a.html | - |
dc.contributor.alternativeName | Kim, Jong Sun | - |
dc.contributor.alternativeName | Lee, Seung Tae | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.affiliatedAuthor | Kim, Jong Sun | - |
dc.contributor.affiliatedAuthor | Lee, Seung Tae | - |
dc.contributor.affiliatedAuthor | Lee, Jae Myun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 85 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 220 | - |
dc.citation.endPage | 228 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY AND CELL BIOLOGY, Vol.85(3) : 220-228, 2007 | - |
dc.identifier.rimsid | 35439 | - |
dc.type.rims | ART | - |
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