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Intralesional injection of OK-432 for vision-threatening orbital lymphangioma

 Jin Sook Yoon  ;  Jung Bum Choi  ;  Sang Yeul Lee  ;  Sung Joo Kim 
 Graefes Archive for Clinical and Experimental Ophthalmology, Vol.245(7) : 1031-1035, 2007 
Journal Title
 Graefes Archive for Clinical and Experimental Ophthalmology 
Issue Date
Antineoplastic Agents/administration & dosage* ; Child, Preschool ; Female ; Humans ; Infant ; Injections, Intralesional ; Lymphangioma/drug therapy* ; Lymphangioma/pathology ; Magnetic Resonance Imaging ; Male ; Orbital Neoplasms/drug therapy* ; Orbital Neoplasms/pathology ; Picibanil/administration & dosage* ; Retreatment ; Tomography, X-Ray Computed
BACKGROUND: Surgical excision of orbital lymphangiomas is difficult, and almost always incomplete due to the diffusely infiltrative pattern of these tumors. The present report describes the successful use of intralesional OK-432 administration to treat two patients with intractable hemorrhagic proptosis due to orbital lymphangiomas. METHODS: A 3-year-old girl (case 1) presented with aggressive proptosis and ptosis, and a 1-year-old boy (case 2) presented with massive proptosis and exposure keratopathy, associated with recurrent intracystic bleeding of an orbital lymphangioma. In case 1, 0.02 mg OK-432 was intracystically injected in a volume of 2 ml of physiologic saline. Due to a lack of therapeutic response, a second injection of 0.05 mg OK-432 in 1 ml was administered. In case 2, a single dose of 0.05 mg OK-432 in 1 ml was administered. RESULTS: In both cases, intracystic administration of 0.05 mg of OK-432 in a 1-ml volume resulted in a successful outcome. The adverse effects were minor (mild transient fever and lid swelling), and rebleeding and intraocular pressure elevation did not occur. Proptosis and eyelid swelling gradually improved over 1 month, and completely resolved within 3 months of treatment. CONCLUSIONS: Intralesional administration of 0.05 mg/ml OK-432 (delivered in 1 ml) resulted in the successful treatment of two cases of orbital lymphangioma. Although this drug concentration is higher than in previous reports, there were no major adverse effects.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Lee, Sang Yeul(이상열)
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