Cited 12 times in
Intralesional injection of OK-432 for vision-threatening orbital lymphangioma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤진숙 | - |
dc.contributor.author | 이상열 | - |
dc.date.accessioned | 2014-12-21T16:38:06Z | - |
dc.date.available | 2014-12-21T16:38:06Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96059 | - |
dc.description.abstract | BACKGROUND: Surgical excision of orbital lymphangiomas is difficult, and almost always incomplete due to the diffusely infiltrative pattern of these tumors. The present report describes the successful use of intralesional OK-432 administration to treat two patients with intractable hemorrhagic proptosis due to orbital lymphangiomas. METHODS: A 3-year-old girl (case 1) presented with aggressive proptosis and ptosis, and a 1-year-old boy (case 2) presented with massive proptosis and exposure keratopathy, associated with recurrent intracystic bleeding of an orbital lymphangioma. In case 1, 0.02 mg OK-432 was intracystically injected in a volume of 2 ml of physiologic saline. Due to a lack of therapeutic response, a second injection of 0.05 mg OK-432 in 1 ml was administered. In case 2, a single dose of 0.05 mg OK-432 in 1 ml was administered. RESULTS: In both cases, intracystic administration of 0.05 mg of OK-432 in a 1-ml volume resulted in a successful outcome. The adverse effects were minor (mild transient fever and lid swelling), and rebleeding and intraocular pressure elevation did not occur. Proptosis and eyelid swelling gradually improved over 1 month, and completely resolved within 3 months of treatment. CONCLUSIONS: Intralesional administration of 0.05 mg/ml OK-432 (delivered in 1 ml) resulted in the successful treatment of two cases of orbital lymphangioma. Although this drug concentration is higher than in previous reports, there were no major adverse effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1031~1035 | - |
dc.relation.isPartOf | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/administration & dosage* | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Injections, Intralesional | - |
dc.subject.MESH | Lymphangioma/drug therapy* | - |
dc.subject.MESH | Lymphangioma/pathology | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Orbital Neoplasms/drug therapy* | - |
dc.subject.MESH | Orbital Neoplasms/pathology | - |
dc.subject.MESH | Picibanil/administration & dosage* | - |
dc.subject.MESH | Retreatment | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Intralesional injection of OK-432 for vision-threatening orbital lymphangioma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.contributor.googleauthor | Jung Bum Choi | - |
dc.contributor.googleauthor | Sang Yeul Lee | - |
dc.contributor.googleauthor | Sung Joo Kim | - |
dc.identifier.doi | 10.1007/s00417-006-0510-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02611 | - |
dc.contributor.localId | A02819 | - |
dc.relation.journalcode | J00951 | - |
dc.identifier.eissn | 1435-702X | - |
dc.identifier.pmid | 17577592 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00417-006-0510-4 | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.alternativeName | Lee, Sang Yeul | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Sook | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 245 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1031 | - |
dc.citation.endPage | 1035 | - |
dc.identifier.bibliographicCitation | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.245(7) : 1031-1035, 2007 | - |
dc.identifier.rimsid | 35401 | - |
dc.type.rims | ART | - |
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