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The role of uninjured C-afferents and injured afferents in the generation of mechanical hypersensitivity after partial peripheral nerve injury in the rat

Authors
 Jun Ho Jang  ;  Kyung Hwa Kim  ;  Joong Woo Leem  ;  Dong-Wook Kim  ;  Kyung Ah Park  ;  Won Taek Lee  ;  Taick Sang Nam 
Citation
 EXPERIMENTAL NEUROLOGY, Vol.204(1) : 288-298, 2007 
Journal Title
 EXPERIMENTAL NEUROLOGY 
ISSN
 0014-4886 
Issue Date
2007
MeSH
Analgesics, Non-Narcotic/pharmacology ; Animals ; Capsaicin/pharmacology ; Ganglia, Spinal/pathology ; Hyperalgesia/etiology* ; Hyperalgesia/physiopathology* ; Ligation ; Lumbosacral Region ; Male ; Nerve Fibers, Unmyelinated* ; Nervous System Diseases/etiology ; Nervous System Diseases/physiopathology ; Neural Conduction ; Neurons, Afferent*/drug effects ; Neurons, Afferent*/pathology ; Nociceptors/physiopathology ; Rats ; Rats, Sprague-Dawley ; Rhizotomy ; Sciatic Nerve/drug effects ; Spinal Nerves/drug effects ; Spinal Nerves/injuries* ; Time Factors
Abstract
This study was performed to determine which of uninjured lumbar 4 (L4) C-afferents and injured L5 afferents was important for the generation of mechanical hypersensitivity following L5 spinal nerve ligation-and-cut (SNLC, modified spinal nerve ligation) in the rat. The mechanical hypersensitivity established following L5 SNLC was completely abolished 6 weeks after local capsaicin treatment of the sciatic nerve or L4 spinal nerve. At this stage, a substantial number of capsaicin-sensitive C-afferents were eliminated without any loss of A-afferents in the L4 spinal segment, suggesting that the capsaicin-sensitive L4 C-afferents are a major contributor to L5 SNLC-produced mechanical hypersensitivity. The peripheral terminals of L4 C-afferents are active in maintaining mechanical hypersensitivity, even long after L5 SNLC. When capsaicin-sensitive L4 C-afferents were previously eliminated, the induction of L5 SNLC-produced hypersensitivity was partly prevented. Thus, capsaicin-sensitive L4 C-afferents are crucial for the induction and maintenance of mechanical hypersensitivity in the L5 SNLC model. Also, when capsaicin-sensitive L4 C-afferents were previously eliminated, L5 SNLC still produced a partial mechanical hypersensitivity for a 1- to 2-week maintenance period with a several-day delay. This mild hypersensitivity was prevented by the previous L5 dorsal rhizotomy, implying an involvement of inputs from injured L5 afferents in the maintenance of hypersensitivity at the earlier stage. The results suggest that uninjured C-afferents, most likely C-polymodal nociceptors, are necessary for the induction and maintenance of neuropathic pain, and that afferent inputs, presumably from injured Aβ-fibers, also contribute to the maintenance at an earlier stage.
Full Text
http://www.sciencedirect.com/science/article/pii/S0014488606006133
DOI
10.1016/j.expneurol.2006.11.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0002-5025-1532
Nam, Taick Sang(남택상)
Park, Kyung Ah(박경아)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Leem, Joong Woo(임중우) ORCID logo https://orcid.org/0000-0002-1605-2230
Jang, Jun Ho(장준호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96033
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