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Derivation of functional dopamine neurons from embryonic stem cells

Authors
 Kim, Dae-Sung  ;  Kim, Ji Young  ;  Kim, Dong-Wook  ;  Cho, Myung Soo  ;  Kang, Minkyung 
Citation
 CELL TRANSPLANTATION, Vol.16(2) : 117-123, 2007 
Journal Title
 CELL TRANSPLANTATION 
ISSN
 0963-6897 
Issue Date
2007
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective degeneration of dopaminergic (DA) neurons in the substantia nigra of the midbrain. Pharmacological treatment of PD has been a prevailing strategy. However, it has some limitations because its effectiveness gradually decreases and side effects develop. As an alternative, cell transplantation therapy has been tried. Although transplantation of fetal ventral mesencephalic cells looks promising for the treatment of PD in some cases, ethical and technical problems in obtaining large numbers of human fetal brain tissues also lead to difficulty in its clinical application. Our recent studies showed that a high yield of DA neurons could be derived from embryonic stem (ES) cells and they efficiently induced behavioral recovery in a PD animal model. Here we summarize methods for generation of functional DA neurons from ES cells for application to PD models.
Full Text
http://www.ingentaconnect.com/content/cog/ct/2007/00000016/00000002/art00003?token=0056160e7ac0fa6e586546243163425e47635d7a706a25445e4e26634a492f25303329760ff87c86560935
DOI
10.3727/000000007783464650
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kang, Min Kyung(강민경)
Kim, Dae Sung(김대성)
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0002-5025-1532
Kim, Ji Young(김지영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95814
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