Cited 28 times in
Derivation of functional dopamine neurons from embryonic stem cells
DC Field | Value | Language |
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dc.contributor.author | 강민경 | - |
dc.contributor.author | 김대성 | - |
dc.contributor.author | 김동욱 | - |
dc.contributor.author | 김지영 | - |
dc.date.accessioned | 2014-12-21T16:30:11Z | - |
dc.date.available | 2014-12-21T16:30:11Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95814 | - |
dc.description.abstract | Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective degeneration of dopaminergic (DA) neurons in the substantia nigra of the midbrain. Pharmacological treatment of PD has been a prevailing strategy. However, it has some limitations because its effectiveness gradually decreases and side effects develop. As an alternative, cell transplantation therapy has been tried. Although transplantation of fetal ventral mesencephalic cells looks promising for the treatment of PD in some cases, ethical and technical problems in obtaining large numbers of human fetal brain tissues also lead to difficulty in its clinical application. Our recent studies showed that a high yield of DA neurons could be derived from embryonic stem (ES) cells and they efficiently induced behavioral recovery in a PD animal model. Here we summarize methods for generation of functional DA neurons from ES cells for application to PD models. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 117~123 | - |
dc.relation.isPartOf | CELL TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Derivation of functional dopamine neurons from embryonic stem cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Kim, Dae-Sung | - |
dc.contributor.googleauthor | Kim, Ji Young | - |
dc.contributor.googleauthor | Kim, Dong-Wook | - |
dc.contributor.googleauthor | Cho, Myung Soo | - |
dc.contributor.googleauthor | Kang, Minkyung | - |
dc.identifier.doi | 10.3727/000000007783464650 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00981 | - |
dc.contributor.localId | A00367 | - |
dc.contributor.localId | A00025 | - |
dc.contributor.localId | A00406 | - |
dc.relation.journalcode | J00492 | - |
dc.identifier.eissn | 1555-3892 | - |
dc.identifier.url | http://www.ingentaconnect.com/content/cog/ct/2007/00000016/00000002/art00003?token=0056160e7ac0fa6e586546243163425e47635d7a706a25445e4e26634a492f25303329760ff87c86560935 | - |
dc.contributor.alternativeName | Kang, Min Kyung | - |
dc.contributor.alternativeName | Kim, Dae Sung | - |
dc.contributor.alternativeName | Kim, Dong Wook | - |
dc.contributor.alternativeName | Kim, Ji Young | - |
dc.contributor.affiliatedAuthor | Kim, Ji Young | - |
dc.contributor.affiliatedAuthor | Kim, Dae Sung | - |
dc.contributor.affiliatedAuthor | Kang, Min Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 123 | - |
dc.identifier.bibliographicCitation | CELL TRANSPLANTATION, Vol.16(2) : 117-123, 2007 | - |
dc.identifier.rimsid | 53224 | - |
dc.type.rims | ART | - |
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