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Homer proteins in Ca2+ signaling by excitable and non-excitable cells

 Paul F. Worley  ;  Weizhong Zeng  ;  Shmuel Muallem  ;  Kirill Kiselyov  ;  Joseph P. Yuan  ;  Min Seuk Kim  ;  Dong Min Shin  ;  Joo Young Kim  ;  Guojin Huang 
 CELL CALCIUM, Vol.42(4-5) : 363-371, 2007 
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Homers are scaffolding proteins that bind Ca2+ signaling proteins in cellular microdomains. The Homers participate in targeting and localization of Ca2+ signaling proteins in signaling complexes. However, recent work showed that the Homers are not passive scaffolding proteins, but rather they regulate the activity of several proteins within the Ca2+ signaling complex in an isoform-specific manner. Homer2 increases the GAP activity of RGS proteins and PLCβ that accelerate the GTPase activity of Gα subunits. Homer1 gates the activity of TRPC channels, controls the rates of their translocation and retrieval from the plasma membrane and mediates the conformational coupling between TRPC channels and IP3Rs. Homer1 stimulates the activity of the cardiac and neuronal L-type Ca2+ channels Cav1.2 and Cav1.3. Homer1 also mediates the communication between the cardiac and smooth muscle ryanodine receptor RyR2 and Cav1.2 to regulate E–C coupling. In many cases the Homers function as a buffer to reduce the intensity of Ca2+ signaling and create a negative bias that can be reversed by the immediate early gene form of Homer1. Hence, the Homers should be viewed as the buffers of Ca2+ signaling that ensure a high spatial and temporal fidelity of the Ca2+ signaling and activation of downstream effects.
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1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Seuk(김민석)
Kim, Joo Young(김주영) ORCID logo https://orcid.org/0000-0003-2623-1491
Shin, Dong Min(신동민) ORCID logo https://orcid.org/0000-0001-6042-0435
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