343 489

Cited 0 times in

Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats

Authors
 Kyung Hee Lee  ;  Haeyoung Suh-Kim  ;  Bae Hwan Lee  ;  Do Heum Yoon  ;  Sung-Soo Kim  ;  Eun Jin Kim  ;  Sin-Soo Jeun  ;  Jisoo Choi 
Citation
 ACTA NEUROBIOLOGIAE EXPERIMENTALIS, Vol.67(1) : 13-22, 2007 
Journal Title
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
ISSN
 0065-1400 
Issue Date
2007
Abstract
Many attempts have been made in animals to produce cellular regeneration in the spinal cord using a variety of transplanted cell types. The present study was to investigate whether transplantation of human mesenchymal stem cells (hMSCs) into the spinal cord after contusion injury promotes a functional outcome. Spinal cord injury (SCI) was induced using an NYU impactor and hMSCs were transplanted 1 week after SCI. Behavioral testing was performed weekly for 2 months. Somatosensory (SSEPs) and motor evoked potentials (MEPs) were recorded to determine functional recovery. Hindlimb performance was modestly improved in the transplanted group based on BBB scaling and pain tests. SSEP latencies in the transplanted group were significantly shorter than in the media-treated group. Pathologically, LacZ and hTau positive cells were located at the injury and adjacent sites. The data indicate improvement in functional outcome in animals treated with hMSC transplantation compared to media-treated animals.
Files in This Item:
T200701021.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Eun Jin(김은진)
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Lee, Kyung Hee(이경희)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95509
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links