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Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats
DC Field | Value | Language |
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dc.contributor.author | 김은진 | - |
dc.contributor.author | 윤도흠 | - |
dc.contributor.author | 이경희 | - |
dc.contributor.author | 이배환 | - |
dc.date.accessioned | 2014-12-21T16:20:27Z | - |
dc.date.available | 2014-12-21T16:20:27Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0065-1400 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95509 | - |
dc.description.abstract | Many attempts have been made in animals to produce cellular regeneration in the spinal cord using a variety of transplanted cell types. The present study was to investigate whether transplantation of human mesenchymal stem cells (hMSCs) into the spinal cord after contusion injury promotes a functional outcome. Spinal cord injury (SCI) was induced using an NYU impactor and hMSCs were transplanted 1 week after SCI. Behavioral testing was performed weekly for 2 months. Somatosensory (SSEPs) and motor evoked potentials (MEPs) were recorded to determine functional recovery. Hindlimb performance was modestly improved in the transplanted group based on BBB scaling and pain tests. SSEP latencies in the transplanted group were significantly shorter than in the media-treated group. Pathologically, LacZ and hTau positive cells were located at the injury and adjacent sites. The data indicate improvement in functional outcome in animals treated with hMSC transplantation compared to media-treated animals. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 13~22 | - |
dc.relation.isPartOf | ACTA NEUROBIOLOGIAE EXPERIMENTALIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Kyung Hee Lee | - |
dc.contributor.googleauthor | Haeyoung Suh-Kim | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | Do Heum Yoon | - |
dc.contributor.googleauthor | Sung-Soo Kim | - |
dc.contributor.googleauthor | Eun Jin Kim | - |
dc.contributor.googleauthor | Sin-Soo Jeun | - |
dc.contributor.googleauthor | Jisoo Choi | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00824 | - |
dc.contributor.localId | A02662 | - |
dc.contributor.localId | A02546 | - |
dc.contributor.localId | A02791 | - |
dc.relation.journalcode | J00017 | - |
dc.identifier.eissn | 1689-0035 | - |
dc.contributor.alternativeName | Kim, Eun Jin | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.alternativeName | Lee, Kyung Hee | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jin | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 67 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13 | - |
dc.citation.endPage | 22 | - |
dc.identifier.bibliographicCitation | ACTA NEUROBIOLOGIAE EXPERIMENTALIS, Vol.67(1) : 13-22, 2007 | - |
dc.identifier.rimsid | 43298 | - |
dc.type.rims | ART | - |
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