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Differential effect of intraperitoneal albendazole and paclitaxel on ascites formation and expression of vascular endothelial growth factor in ovarian cancer cell-bearing athymic nude mice.

Authors
 Eun-Kyoung Choi  ;  Sang-Wun Kim  ;  Eun-Ji Nam  ;  Jiheum Pa다  ;  Ga-Won Yim  ;  Myeong-Hwa Kang  ;  Young-Tae Kim 
Citation
 REPRODUCTIVE SCIENCES, Vol.18(8) : 763-771, 2011 
Journal Title
REPRODUCTIVE SCIENCES
ISSN
 1933-7191 
Issue Date
2011
MeSH
Albendazole/administration & dosage ; Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/pharmacology* ; Ascites/metabolism ; Female ; Mice ; Mice, Nude ; Ovarian Neoplasms/drug therapy* ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Paclitaxel/administration & dosage ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Tubulin Modulators/administration & dosage ; Vascular Endothelial Growth Factor A/biosynthesis* ; Vascular Endothelial Growth Factor A/genetics
Keywords
albendazole ; paclitaxel ; ascites ; vascular endothelial growth factor ; ovarian carcinoma
Abstract
OBJECTIVES: The purposes of our study were to evaluate the effect of intraperitoneal albendazole on tumor growth, ascites formation, and vascular endothelial growth factor (VEGF) mRNA expression, and to assess the synergistic effect of paclitaxel in OVCAR-3-bearing nude mice.

METHODS: In all, 4 groups of mice were injected intraperitoneally with weekly albendazole (450 mg/kg per week), paclitaxel (30 mg/kg per week), albendazole plus paclitaxel, or normal saline for 4 weeks.

RESULTS: Ascitic fluid accumulation (2.47, 2.65, 2.88, and 5.90 mL, respectively) and in ascitic VEGF levels were significantly reduced in the 3 treatment groups compared to the control group (170.83, 229.16, 267, and 1625 pg/mL, respectively). However, complete tumor suppression was more prominent in the paclitaxel group, and VEGF mRNA expression was more strongly inhibited in the albendazole group (P < .05). No synergistic effect of albendazole and paclitaxel was observed.

CONCLUSION: We demonstrated a differential effect of albendazole and paclitaxel in a xenograft model of ovarian carcinoma; albendazole suppressed ascites formation by inhibiting VEGF secretion, and paclitaxel exerted its effects by direct cytotoxicity.
Full Text
http://rsx.sagepub.com/content/18/8/763
DOI
10.1177/1933719111398142
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Myung Hwa(강명화)
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Nam, Eun Ji(남은지) ORCID logo https://orcid.org/0000-0003-0189-3560
Yim, Ga Won(임가원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95447
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