Cited 11 times in
Differential effect of intraperitoneal albendazole and paclitaxel on ascites formation and expression of vascular endothelial growth factor in ovarian cancer cell-bearing athymic nude mice.
DC Field | Value | Language |
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dc.contributor.author | 남은지 | - |
dc.contributor.author | 임가원 | - |
dc.contributor.author | 강명화 | - |
dc.contributor.author | 김상운 | - |
dc.contributor.author | 김영태 | - |
dc.date.accessioned | 2014-12-20T17:53:21Z | - |
dc.date.available | 2014-12-20T17:53:21Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1933-7191 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95447 | - |
dc.description.abstract | OBJECTIVES: The purposes of our study were to evaluate the effect of intraperitoneal albendazole on tumor growth, ascites formation, and vascular endothelial growth factor (VEGF) mRNA expression, and to assess the synergistic effect of paclitaxel in OVCAR-3-bearing nude mice. METHODS: In all, 4 groups of mice were injected intraperitoneally with weekly albendazole (450 mg/kg per week), paclitaxel (30 mg/kg per week), albendazole plus paclitaxel, or normal saline for 4 weeks. RESULTS: Ascitic fluid accumulation (2.47, 2.65, 2.88, and 5.90 mL, respectively) and in ascitic VEGF levels were significantly reduced in the 3 treatment groups compared to the control group (170.83, 229.16, 267, and 1625 pg/mL, respectively). However, complete tumor suppression was more prominent in the paclitaxel group, and VEGF mRNA expression was more strongly inhibited in the albendazole group (P < .05). No synergistic effect of albendazole and paclitaxel was observed. CONCLUSION: We demonstrated a differential effect of albendazole and paclitaxel in a xenograft model of ovarian carcinoma; albendazole suppressed ascites formation by inhibiting VEGF secretion, and paclitaxel exerted its effects by direct cytotoxicity. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | REPRODUCTIVE SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Albendazole/administration & dosage | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/administration & dosage | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/pharmacology* | - |
dc.subject.MESH | Ascites/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Ovarian Neoplasms/drug therapy* | - |
dc.subject.MESH | Ovarian Neoplasms/genetics | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism | - |
dc.subject.MESH | Paclitaxel/administration & dosage | - |
dc.subject.MESH | RNA, Messenger/biosynthesis | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Tubulin Modulators/administration & dosage | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/biosynthesis* | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/genetics | - |
dc.title | Differential effect of intraperitoneal albendazole and paclitaxel on ascites formation and expression of vascular endothelial growth factor in ovarian cancer cell-bearing athymic nude mice. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Eun-Kyoung Choi | - |
dc.contributor.googleauthor | Sang-Wun Kim | - |
dc.contributor.googleauthor | Eun-Ji Nam | - |
dc.contributor.googleauthor | Jiheum Pa다 | - |
dc.contributor.googleauthor | Ga-Won Yim | - |
dc.contributor.googleauthor | Myeong-Hwa Kang | - |
dc.contributor.googleauthor | Young-Tae Kim | - |
dc.identifier.doi | 10.1177/1933719111398142 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04147 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A03354 | - |
dc.contributor.localId | A00020 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00729 | - |
dc.relation.journalcode | J02606 | - |
dc.identifier.eissn | 1933-7205 | - |
dc.identifier.pmid | 21421899 | - |
dc.identifier.url | http://rsx.sagepub.com/content/18/8/763 | - |
dc.subject.keyword | albendazole | - |
dc.subject.keyword | paclitaxel | - |
dc.subject.keyword | ascites | - |
dc.subject.keyword | vascular endothelial growth factor | - |
dc.subject.keyword | ovarian carcinoma | - |
dc.contributor.alternativeName | Nam, Eun Ji | - |
dc.contributor.alternativeName | Yim, Ga Won | - |
dc.contributor.alternativeName | Choi, Eun Kyoung | - |
dc.contributor.alternativeName | Kang, Myung Hwa | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Choi, Eun Kyoung | - |
dc.contributor.affiliatedAuthor | Nam, Eun Ji | - |
dc.contributor.affiliatedAuthor | Yim, Ga Won | - |
dc.contributor.affiliatedAuthor | Kang, Myung Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Sang Wun | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 763 | - |
dc.citation.endPage | 771 | - |
dc.identifier.bibliographicCitation | REPRODUCTIVE SCIENCES, Vol.18(8) : 763-771, 2011 | - |
dc.identifier.rimsid | 40822 | - |
dc.type.rims | ART | - |
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