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The humoral immune response to the inactivated influenza A (H1N1) 2009 monovalent vaccine in patients with Type 2 diabetes mellitus in Korea.

Authors
 J. S. Nam  ;  A. R. Kim  ;  J. C. Yoon  ;  Y. Byun  ;  S. A. Kim  ;  K. R. Kim  ;  S. Cho  ;  B. L. Seong  ;  C. W. Ahn  ;  J. M. Lee 
Citation
 Diabetic Medicine, Vol.28(7) : 815-817, 2011 
Journal Title
 Diabetic Medicine 
ISSN
 0742-3071 
Issue Date
2011
MeSH
Adolescent ; Adult ; Aged ; Antibodies, Viral/immunology ; Antibody Formation/immunology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/immunology* ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunity, Humoral ; Influenza A Virus, H1N1 Subtype/immunology* ; Influenza Vaccines/immunology* ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control* ; Korea/epidemiology ; Male ; Middle Aged ; Risk Factors ; Young Adult
Keywords
antibody seroconversion ; influenza A (H1N1) ; 2009 monovalent vaccine ; Type 2 diabetes mellitus
Abstract
AIMS: We evaluated the antibody response to a single-dose adjuvanted, inactivated, pandemic H1N1 influenza vaccination in patients with diabetes and assessed factors associated with the failure to induce antibody responses. METHODS: Eighty-two patients with Type 2 diabetes were vaccinated and antibody responses were determined with haemagglutination inhibition assay and anti-haemagglutinin antibody ELISA. RESULTS: Among 70 antibody-negative patients at baseline, 34 (48.6%) achieved seroconversion; 28 (60.9%) in the young adults group and six (25%) in the elderly group acquired H1N1-specific antibodies. Patients in the older age range or with longer duration of diabetes had a lower seroconversion rate. CONCLUSIONS: Our data show low cross-reactive antibody carrying rate and low seroconversion rate in patients with diabetes. Until larger-scale, case-controlled trials become available, older patients and patients with a longer duration of diabetes should be considered for the two-dose vaccination or have antibody titres measured after the first vaccination.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2011.03255.x/abstract
DOI
10.1111/j.1464-5491.2011.03255.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Ah Reum(김아름) ORCID logo https://orcid.org/0000-0001-5938-4270
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoon, Joo Chun(윤주천)
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95434
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