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Screening and Treating Wernicke's Encephalopathy among Alcoholic Patients in a University Hospital

 Lee S  ;  Lee SY  ;  Namkoong K.  ;  Jung YC  ;  Kim E  ;  Ha RY 
 Journal of the Korean Neuropsychiatric Association (신경정신의학), Vol.50(4) : 323-328, 2011 
Journal Title
 Journal of the Korean Neuropsychiatric Association  (신경정신의학) 
Issue Date
OBJECTIVES: The purpose of this study was to investigate the prevalence and clinical characteristics of Wernicke's encephalopathy (WE) patients in alcoholics and to evaluate the utility of Caine's criteria as a screening test. METHODS: We made an admission note including Caine's criteria and applied it to patients who were admitted to an alcohol treatment unit. Demographic, clinical, and laboratory data were collected on 204 alcoholics. Our alcoholics who met more than one of Caine's criteria were considered at risk for WE and were given high-dose thiamine IV therapy. RESULTS: We was diagnosed in 15.2% of the alcoholic patients. Age and head trauma history were risk factors of WE. The sensitivity of Caine's criteria was 97% and specificity was 54%. High-dose thiamine IV therapy appeared to be a safe and cost-effective method to prevent the serious complications of WE. CONCLUSION: Caine's criteria is useful as a screening test for WE among alcoholic patients. High-dose thiamine IV therapy is cost-effective for alcoholic patients who are considered to be at risk for WE.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김어수(Kim, Eo Su) ; 남궁기(Namkoong, Kee) ; 이서정(Lee, Seo Jung) ; 정영철(Jung, Young Chul) ; 하라연(Ha, Ra Yeon)
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