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Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD

Authors
 Sung Hee Lee  ;  So Won Kim  ;  Min Goo Lee  ;  Ki-Hwan Yook  ;  Laurence L. Greenhill  ;  Kelly N. Frandinc  ;  Hyun Ju Hong 
Citation
 PSYCHIATRY RESEARCH-NEUROIMAGING, Vol.186(2-3) : 338-344, 2011 
Journal Title
PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN
 0925-4927 
Issue Date
2011
MeSH
Adult ; Attention Deficit Disorder with Hyperactivity/genetics* ; Central Nervous System Stimulants/therapeutic use* ; Female ; Gene Frequency ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Korea ; Linkage Disequilibrium ; Male ; Methylphenidate/therapeutic use* ; Norepinephrine Plasma Membrane Transport Proteins/genetics* ; Polymorphism, Single Nucleotide/genetics* ; Retrospective Studies ; Young Adult
Keywords
ADHD ; Methylphenidate ; Norepinephrine transporter ; Pharmacogenetics ; Polymorphism
Abstract
This study investigated the relationship between the five common polymorphisms (rs2242446, rs5568, rs5569, rs998424, and rs1616905) in the norepinephrine transporter (NET) gene and the OROS-methylphenidate response in a medication-naïve Korean attention-deficit hyperactivity disorder (ADHD) sample. One hundred thirty-seven patients with ADHD were recruited from the child and adolescent psychiatric outpatient units. The trial was an eight-week, open-label study of OROS-methylphenidate monotherapy, and treatment outcomes were measured using the Korean version of the ADHD Rating Scales-IV (K-ARS) for the parents, the Clinician Global Impression Severity Scale (CGI-S) and the Clinician Global Impression Improvement Scale (CGI-I). Associations between the five NET polymorphisms and the drug response were analyzed using genotype and allele frequencies at each locus. There was no significant difference in genotype and allele distribution for each NET polymorphism between responders and non-responders (P>0.05). There were no significant differences in change of the K-ARS score, change of CGI-S scores or CGI-I scores at 8 weeks among each genotype and allele of five NET polymorphisms (P>0.05). Although there were no significant positive results, our findings may have several implications and offer direction for future studies.
Full Text
http://www.sciencedirect.com/science/article/pii/S016517811000541X
DOI
10.1016/j.psychres.2010.08.033
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, So Won(김소원)
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Lee, Sung Hee(이성희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95252
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