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The cystic fibrosis transmembrane conductance regulator's expanding SNARE interactome

Authors
 Bor Luen Tang  ;  Heon Yung Gee  ;  Min Goo Lee 
Citation
 Traffic, Vol.12(4) : 364-371, 2011 
Journal Title
 Traffic 
ISSN
 1398-9219 
Issue Date
2011
MeSH
Animals ; Chloride Channels/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism* ; Humans ; Protein Binding ; Protein Transport ; SNARE Proteins/metabolism*
Abstract
The cystic fibrosis transmembrane conductance regulator (CFTR) interacts with multiple N-ethylmaleimide sensitive factor attachment protein (SNARE) molecules largely via its N-terminal cytoplasmic domain. The earliest known among these SNAREs are the cognate Q-SNARE pair of Syntaxin 1A (STX1A) and SNAP23 on the plasma membrane. These SNAREs affect CFTR chloride channel gating. CFTR exocytosis/recycling in intestinal epithelial cells is dependent on another SNARE located in the apical plasma membrane, STX3. Members of the STX8/STX7/vesicle transport through interaction with t-SNAREs homolog 1b/VAMP8 SNARE complex, which function in early to late endosome/lysosome traffic, are all known to interact with CFTR. Two SNAREs, STX6 and STX16 that function at the trans-Golgi network (TGN), have now been revealed as members of the CFTR SNARE interactome. We summarize here the SNAREs that interact with CFTR and discuss the roles of these SNAREs in the intracellular trafficking of CFTR and CFTR-associated pathophysiology.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0854.2011.01161.x/abstract
DOI
10.1111/j.1600-0854.2011.01161.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Gee, Heon Yung(지헌영) ORCID logo https://orcid.org/0000-0002-8741-6177
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95250
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