2 200

Cited 3 times in

The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis

Authors
 Su Na Kim  ;  Hyun Pyo Shim  ;  Bu-Nam Jeon  ;  Won-Il Choi  ;  Man-Wook Hur  ;  Jack R. Girton  ;  Sang Hee Kim  ;  Sang-Hak Jeon 
Citation
 MOLECULES AND CELLS, Vol.32(6) : 549-554, 2011 
Journal Title
 MOLECULES AND CELLS 
ISSN
 1016-8478 
Issue Date
2011
MeSH
Animals ; Blastoderm/metabolism ; Cells, Cultured ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/physiology* ; Drosophila Proteins/genetics* ; Drosophila Proteins/metabolism ; Drosophila Proteins/physiology* ; Drosophila melanogaster/embryology ; Drosophila melanogaster/genetics* ; Embryonic Development/genetics* ; Female ; Gene Expression Regulation, Developmental ; Homeodomain Proteins/genetics* ; Homeodomain Proteins/metabolism ; Larva/anatomy & histology ; Larva/metabolism ; Mutation ; Polycomb-Group Proteins ; Promoter Regions, Genetic ; Protein Binding ; Transcription Factors/genetics* ; Transcription Factors/metabolism ; Transcription Factors/physiology*
Keywords
eve ; Drosophila melanogaster ; GAGA ; pleiohomeotic ; Polycomb group genes ; PRE ; segmentation genes
Abstract
Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.
Full Text
http://link.springer.com/article/10.1007%2Fs10059-011-0173-9
DOI
10.1007/s10059-011-0173-9
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Jeon, Bu Nam(전부남)
Choi, Won Il(최원일)
Hur, Man Wook(허만욱) ORCID logo https://orcid.org/0000-0002-3416-1334
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95225
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links