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The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis

Authors
 Su Na Kim ; Hyun Pyo Shim ; Sang-Hak Jeon ; Sang Hee Kim ; Jack R. Girton ; Man-Wook Hur ; Won-Il Choi ; Bu-Nam Jeon 
Citation
 Molecules and Cells, Vol.32(6) : 549~554, 2011 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2011
Abstract
Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/95225
DOI
10.1007/s10059-011-0173-9
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Life Science
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs10059-011-0173-9
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