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The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis

Authors
 Su Na Kim  ;  Hyun Pyo Shim  ;  Sang-Hak Jeon  ;  Sang Hee Kim  ;  Jack R. Girton  ;  Man-Wook Hur  ;  Won-Il Choi  ;  Bu-Nam Jeon 
Citation
 Molecules and Cells, Vol.32(6) : 549-554, 2011 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2011
Abstract
Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95225
DOI
10.1007/s10059-011-0173-9
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Life Science (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry & Molecular Biology (생화학-분자생물학교실)
Yonsei Authors
전부남(Jeon, Bu Nam) ; 최원일(Choi, Won Il) ; 허만욱(Hur, Man Wook)
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Full Text
http://link.springer.com/article/10.1007%2Fs10059-011-0173-9
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