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Unlocking SOAR releases STIM

Authors
 Joo Young Kim ; Shmuel Muallem 
Citation
 EMBO Journal, Vol.30(9) : 1673~1675, 2011 
Journal Title
 EMBO Journal 
ISSN
 0261-4189 
Issue Date
2011
Abstract
A crucial component of the receptor-evoked Ca(2+) signal is Ca(2+) influx mediated by the store-operated Ca(2+) channels (SOCs). The molecular makeup of one SOC is the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming Orai1. Ca(2+) release from the ER leads to co-clustering of STIM1 and Orai1 to activate Orai1. The short STIM1 SOAR/CAD domain (STIM1 Orai1-activating region/CRAC-activating domain), which has two coiledcoil (C–C) domains, interacts with the Orai1 C terminus C–C domain to activate the channel. How the function of SOAR is regulated is not known. Korzeniowski et al (2010) and Muik et al (2011; this issue) now identified an autoinhibitory domain in STIM1 that occludes SOAR. Release of SOAR involves a conformational transition that is aided by the Orai1 C–C domain
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/95210
DOI
10.1038/emboj.2011.107
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pharmacology
Yonsei Authors
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