Cited 15 times in
Unlocking SOAR releases STIM
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주영 | - |
dc.date.accessioned | 2014-12-20T17:45:38Z | - |
dc.date.available | 2014-12-20T17:45:38Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95210 | - |
dc.description.abstract | A crucial component of the receptor-evoked Ca(2+) signal is Ca(2+) influx mediated by the store-operated Ca(2+) channels (SOCs). The molecular makeup of one SOC is the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming Orai1. Ca(2+) release from the ER leads to co-clustering of STIM1 and Orai1 to activate Orai1. The short STIM1 SOAR/CAD domain (STIM1 Orai1-activating region/CRAC-activating domain), which has two coiledcoil (C–C) domains, interacts with the Orai1 C terminus C–C domain to activate the channel. How the function of SOAR is regulated is not known. Korzeniowski et al (2010) and Muik et al (2011; this issue) now identified an autoinhibitory domain in STIM1 that occludes SOAR. Release of SOAR involves a conformational transition that is aided by the Orai1 C–C domain | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1673~1675 | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Calcium/metabolism* | - |
dc.subject.MESH | Calcium Channels/metabolism* | - |
dc.subject.MESH | Calcium Signaling/physiology* | - |
dc.subject.MESH | Endoplasmic Reticulum/metabolism* | - |
dc.subject.MESH | Membrane Proteins/metabolism* | - |
dc.subject.MESH | Models, Molecular* | - |
dc.subject.MESH | Multiprotein Complexes/metabolism* | - |
dc.subject.MESH | Neoplasm Proteins/metabolism* | - |
dc.subject.MESH | ORAI1 Protein | - |
dc.subject.MESH | Protein Conformation | - |
dc.subject.MESH | Protein Structure, Tertiary | - |
dc.subject.MESH | Stromal Interaction Molecule 1 | - |
dc.title | Unlocking SOAR releases STIM | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Joo Young Kim | - |
dc.contributor.googleauthor | Shmuel Muallem | - |
dc.identifier.doi | 10.1038/emboj.2011.107 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00942 | - |
dc.relation.journalcode | J00763 | - |
dc.identifier.eissn | 1460-2075 | - |
dc.identifier.pmid | 21540881 | - |
dc.contributor.alternativeName | Kim, Joo Young | - |
dc.contributor.affiliatedAuthor | Kim, Joo Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1673 | - |
dc.citation.endPage | 1675 | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, Vol.30(9) : 1673-1675, 2011 | - |
dc.identifier.rimsid | 28177 | - |
dc.type.rims | ART | - |
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