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Cited 15 times in

Unlocking SOAR releases STIM

DC Field Value Language
dc.contributor.author김주영-
dc.date.accessioned2014-12-20T17:45:38Z-
dc.date.available2014-12-20T17:45:38Z-
dc.date.issued2011-
dc.identifier.issn0261-4189-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95210-
dc.description.abstractA crucial component of the receptor-evoked Ca(2+) signal is Ca(2+) influx mediated by the store-operated Ca(2+) channels (SOCs). The molecular makeup of one SOC is the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming Orai1. Ca(2+) release from the ER leads to co-clustering of STIM1 and Orai1 to activate Orai1. The short STIM1 SOAR/CAD domain (STIM1 Orai1-activating region/CRAC-activating domain), which has two coiledcoil (C–C) domains, interacts with the Orai1 C terminus C–C domain to activate the channel. How the function of SOAR is regulated is not known. Korzeniowski et al (2010) and Muik et al (2011; this issue) now identified an autoinhibitory domain in STIM1 that occludes SOAR. Release of SOAR involves a conformational transition that is aided by the Orai1 C–C domain-
dc.description.statementOfResponsibilityopen-
dc.format.extent1673~1675-
dc.relation.isPartOfEMBO JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCalcium/metabolism*-
dc.subject.MESHCalcium Channels/metabolism*-
dc.subject.MESHCalcium Signaling/physiology*-
dc.subject.MESHEndoplasmic Reticulum/metabolism*-
dc.subject.MESHMembrane Proteins/metabolism*-
dc.subject.MESHModels, Molecular*-
dc.subject.MESHMultiprotein Complexes/metabolism*-
dc.subject.MESHNeoplasm Proteins/metabolism*-
dc.subject.MESHORAI1 Protein-
dc.subject.MESHProtein Conformation-
dc.subject.MESHProtein Structure, Tertiary-
dc.subject.MESHStromal Interaction Molecule 1-
dc.titleUnlocking SOAR releases STIM-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorJoo Young Kim-
dc.contributor.googleauthorShmuel Muallem-
dc.identifier.doi10.1038/emboj.2011.107-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00942-
dc.relation.journalcodeJ00763-
dc.identifier.eissn1460-2075-
dc.identifier.pmid21540881-
dc.contributor.alternativeNameKim, Joo Young-
dc.contributor.affiliatedAuthorKim, Joo Young-
dc.rights.accessRightsfree-
dc.citation.volume30-
dc.citation.number9-
dc.citation.startPage1673-
dc.citation.endPage1675-
dc.identifier.bibliographicCitationEMBO JOURNAL, Vol.30(9) : 1673-1675, 2011-
dc.identifier.rimsid28177-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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