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Clinical significance of B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Authors
 Jin Seok Kim  ;  Soo-Jeong Kim  ;  June-Won Cheong  ;  Yundeok Kim  ;  Doh Yu Hwang  ;  Sulhee Yoon  ;  Jieun Jang  ;  Shin Young Hyun  ;  Yoo Hong Min 
Citation
 Korean Journal of Hematology, Vol.46(3) : 175-179, 2011 
Journal Title
Korean Journal of Hematology
ISSN
 1738-7949 
Issue Date
2011
Keywords
A proliferation-inducing ligand (APRIL) ; Acute graft-versus-host disease ; Allogeneic hematopoietic stem cell transplantation ; B cell-activating factor (BAFF
Abstract
proliferation. We evaluated the correlation between serum concentration of BAFF or APRIL and severity of acute graft-versus-host disease (GVHD). METHODS: Fifteen patients who received allogeneic hematopoietic stem transplantation for leukemia and developed acute GVHD were enrolled. We determined serum concentrations of BAFF and APRIL at the onset of the first clinical manifestation of GVHD by enzyme-linked immunosorbent assay. RESULTS: Nine patients had grade 2 acute GVHD, and 6 had grade 3-4 acute GVHD. The BAFF serum concentration was higher in patients with grade 3-4 acute GVHD (1,093.42 in grade 2 vs. 2,171.99 pg/mL in grade 3-4), although the difference was not significant (P=0.077). However, the ratio of BAFF serum concentration to absolute lymphocyte count (ALC) (BAFF/ALC) was significantly higher in patients with grade 3-4 acute GVHD (P=0.045). The APRIL serum concentration and APRIL/ALC ratio showed similar results (P=0.077 and P=0.013, respectively). CONCLUSION: Patients with grade 3-4 acute GVHD had higher BAFF/ALC and APRIL/ALC ratios than patients with grade 2 acute GVHD. These findings suggest that B cells might play an important role in the development of acute GVHD, and that the BAFF and APRIL concentrations in serum might be significant predictive factors for estimating the severity of acute GVHD. Their clinical significance should be further evaluated in a larger patient population
Files in This Item:
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DOI
10.5045/kjh.2011.46.3.175
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Kim, Yun Deok(김윤덕) ORCID logo https://orcid.org/0000-0002-5336-7936
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Yoon, Sul Hee(윤설희)
Jang, Ji Eun(장지은) ORCID logo https://orcid.org/0000-0001-8832-1412
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Hyun, Shin Yong(현신영) ORCID logo https://orcid.org/0000-0002-8137-8675
Hwang, Doh Yu(황도유) ORCID logo https://orcid.org/0000-0002-0750-0011
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95101
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