Cited 8 times in
Clinical significance of B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
DC Field | Value | Language |
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dc.contributor.author | 황도유 | - |
dc.contributor.author | 김수정 | - |
dc.contributor.author | 김윤덕 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 윤설희 | - |
dc.contributor.author | 장지은 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 현신영 | - |
dc.date.accessioned | 2014-12-20T17:42:10Z | - |
dc.date.available | 2014-12-20T17:42:10Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1738-7949 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95101 | - |
dc.description.abstract | proliferation. We evaluated the correlation between serum concentration of BAFF or APRIL and severity of acute graft-versus-host disease (GVHD). METHODS: Fifteen patients who received allogeneic hematopoietic stem transplantation for leukemia and developed acute GVHD were enrolled. We determined serum concentrations of BAFF and APRIL at the onset of the first clinical manifestation of GVHD by enzyme-linked immunosorbent assay. RESULTS: Nine patients had grade 2 acute GVHD, and 6 had grade 3-4 acute GVHD. The BAFF serum concentration was higher in patients with grade 3-4 acute GVHD (1,093.42 in grade 2 vs. 2,171.99 pg/mL in grade 3-4), although the difference was not significant (P=0.077). However, the ratio of BAFF serum concentration to absolute lymphocyte count (ALC) (BAFF/ALC) was significantly higher in patients with grade 3-4 acute GVHD (P=0.045). The APRIL serum concentration and APRIL/ALC ratio showed similar results (P=0.077 and P=0.013, respectively). CONCLUSION: Patients with grade 3-4 acute GVHD had higher BAFF/ALC and APRIL/ALC ratios than patients with grade 2 acute GVHD. These findings suggest that B cells might play an important role in the development of acute GVHD, and that the BAFF and APRIL concentrations in serum might be significant predictive factors for estimating the severity of acute GVHD. Their clinical significance should be further evaluated in a larger patient population | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 175~179 | - |
dc.relation.isPartOf | Korean Journal of Hematology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical significance of B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Soo-Jeong Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Yundeok Kim | - |
dc.contributor.googleauthor | Doh Yu Hwang | - |
dc.contributor.googleauthor | Sulhee Yoon | - |
dc.contributor.googleauthor | Jieun Jang | - |
dc.contributor.googleauthor | Shin Young Hyun | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.identifier.doi | 10.5045/kjh.2011.46.3.175 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04457 | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A00790 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A02567 | - |
dc.contributor.localId | A03477 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A04381 | - |
dc.relation.journalcode | J02033 | - |
dc.identifier.pmid | 22065972 | - |
dc.subject.keyword | A proliferation-inducing ligand (APRIL) | - |
dc.subject.keyword | Acute graft-versus-host disease | - |
dc.subject.keyword | Allogeneic hematopoietic stem cell transplantation | - |
dc.subject.keyword | B cell-activating factor (BAFF | - |
dc.contributor.alternativeName | Hwang, Doh Yu | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.alternativeName | Kim, Yun Deok | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Yoon, Sul Hee | - |
dc.contributor.alternativeName | Jang, Ji Eun | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.alternativeName | Hyun, Shin Yong | - |
dc.contributor.affiliatedAuthor | Hwang, Doh Yu | - |
dc.contributor.affiliatedAuthor | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Yun Deok | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Yoon, Sul Hee | - |
dc.contributor.affiliatedAuthor | Jang, Ji Eun | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Hyun, Shin Yong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 175 | - |
dc.citation.endPage | 179 | - |
dc.identifier.bibliographicCitation | Korean Journal of Hematology, Vol.46(3) : 175-179, 2011 | - |
dc.identifier.rimsid | 28094 | - |
dc.type.rims | ART | - |
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