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Resolution of surgically created three-wall intrabony defects in implants using three different biomaterials: an in vivo study

Authors
 Jung-Yoo Choi  ;  Ui-Won Jung  ;  In-Seop Lee  ;  Chang -Sung Kim  ;  Yong-Keun Lee  ;  Seong-Ho Choi 
Citation
 CLINICAL ORAL IMPLANTS RESEARCH, Vol.22(3) : 343-348, 2011 
Journal Title
CLINICAL ORAL IMPLANTS RESEARCH
ISSN
 0905-7161 
Issue Date
2011
MeSH
Alveolar Bone Loss/pathology ; Alveolar Bone Loss/surgery* ; Alveolar Process/pathology ; Animals ; Biocompatible Materials/therapeutic use* ; Bone Regeneration/physiology ; Bone Substitutes/therapeutic use* ; Bone Transplantation/methods* ; Calcium Phosphates/therapeutic use* ; Coated Materials, Biocompatible/chemistry ; Dental Implants* ; Dental Materials/chemistry ; Dental Prosthesis Design ; Dogs ; Male ; Mandible/pathology ; Mandible/surgery* ; Mandibular Diseases/pathology ; Mandibular Diseases/surgery* ; Microscopy, Electron, Scanning ; Nanostructures/chemistry ; Osseointegration/physiology ; Osteogenesis/physiology* ; Spectrometry, X-Ray Emission ; Surface Properties ; Titanium/chemistry ; Tooth Socket/pathology ; Tooth Socket/surgery ; Transplantation, Homologous
Keywords
biomaterials ; calcium phosphate ; defect ; dental implants ; osseointegration ; synthetic bone graft
Abstract
OBJECTIVES: To histomorphometrically analyze bone formation on amorphous calcium phosphate (ACP), micro-macroporous biphasic calcium phosphate (MBCP), and freeze-dried bone allograft (FDBA) in three-wall defects adjacent to structured surface with calcium phosphate nanocoating implants in dogs.

MATERIALS AND METHODS: Five male mixed-breed dogs were used in this study. The premolars and molars were extracted on both sides of the mandible. Eight weeks after extraction, four implants were submerged on each side of the mandible. Three-wall intrabony defects (5 × 3 × 3 mm) were surgically created adjacent to the implants before installation. No grafts were placed in the control group. At the experimental sites, each intrabony defect was grafted with either ACP, MBCP, or FDBA. The dogs were sacrificed after 12 weeks, and histological and histomorphometrical analyses of the implant sites were performed.

RESULTS: All of the three experimental groups exhibited defect resolution and osseointegration that showed a statistically significant difference compared with the control group in terms of remaining defect depth and bone-to-implant contact (BIC). However, there were no statistical significances among the three experimental groups. MBCP had the highest BIC (63.57 ± 21.57%), followed by ACP and FDBA. The control group showed the least bone area and the greatest remaining defect depth.

CONCLUSION: Grafts with the synthetic biomaterials ACP and MBCP showed bone regeneration that was similar to FDBA in surgically created three-wall intrabony defects adjacent to implants. Within the limitations of this study, it can be concluded that ACP and MBCP synthetic biomaterials are as effective as FDBA at osteoconduction.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0501.2010.01978.x/abstract
DOI
10.1111/j.1600-0501.2010.01978.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Lee, Yong Keun(이용근)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94902
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