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사람면역결핍바이러스 감염 환자의 폐동맥 고혈압 발생빈도 및 임상양상

Other Titles
 Prevalence and Clinical Characteristics of Pulmonary Arterial Hypertension in Human Immunodeficiency Virus-Infected Patients 
 김미현  ;  장혁재  ;  김준명  ;  최준용  ;  한상훈  ;  신소연  ;  정남식  ;  하종원  ;  심지영  ;  양우인  ;  강민경  ;  홍지영  ;  양영준 
 Korean Journal of Medicine, Vol.81(6) : 729-739, 2011 
Journal Title
 Korean Journal of Medicine 
Issue Date
Background/Aims: Human immunodeficiency virus-associated pulmonary arterial hypertension (HIV-PAH) is a complication of HIV infection. Due to improvements in HIV survival rates following the introduction of highly active antiretroviral therapy, HIV-PAH has become an important cause of HIV-related morbidity. Thus, the objective of this study was to explore the prevalence and characteristics of HIV-PAH. Methods: Ninety-two patients were enrolled in the study from March to August 2010. We investigated clinical characteristics and performed echocardiography. HIV-PAH was defined as having a mean pulmonary arterial pressure (mPAP)≥25 mmHg based on Mahan`s equation, without lung disease or heart disease. The HIV-PAH-possible group was defined as having a tricuspid regurgitation velocity (TRV) of 2.9-3.4 m/s and a pulmonary arterial systolic pressure (PASP) of 37-50 mmHg. Results: Fifteen patients (16.3%) met the criteria of HIV-PAH based on mPAP. With respect to TRV, six patients met the criteria of the HIV-PAH-possible group. Based on the criteria of mPAP, the duration of HIV infection was not different with or without HIV-PAH. HIV RNA titers and CD4 T cell counts tended to be higher in HIV-PAH patients (8,607±11 vs. 1,067±64 copies/mL, p=0.371; 471±148 vs. 499±252 cells/mm3, p=0.680, respectively). Echocardiographic indices of the right ventricle were significantly deteriorated in the HIV-PAH group as compared with the non-HIV-PAH group (TASPE: 20.52 vs. 23.2, p=0.001; Tei index: 0.42 vs. 0.39, p=0.037). In a multivariate regression analysis, HIV activity factors (HIV duration, HIV RNA titer, and CD4 cell count) were not associated with echocardiographic indices of PAH (mPAP, PASP, and pulmonary vascular resistance). Conclusions: In this study, the prevalence of HIV-PAH was comparable to that of previous studies.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강민경(Kang, Min Kyung) ; 김미현(Kim, Mi Hyun) ; 김준명(Kim, June Myung) ; 신소연(Shin, So Youn) ; 심지영(Shim, Chi Young) ; 양영준(Yang, Young June) ; 양우인(Yang, Woo In) ; 장혁재(Chang, Hyuck Jae) ; 정남식(Chung, Nam Sik) ; 최준용(Choi, Jun Yong) ; 하종원(Ha, Jong Won) ; 한상훈(Han, Sang Hoon) ; 홍지영(Hong , Ji Young)
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