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Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Authors
 Jérémy RICCI  ;  Minkyu KIM  ;  Won-Yoon CHUNG  ;  Kwang-Kyun PARK  ;  Mankil JUNG 
Citation
 CHEMICAL & PHARMACEUTICAL BULLETIN, Vol.59(12) : 1471-1475, 2011 
Journal Title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN
 0009-2363 
Issue Date
2011
MeSH
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry* ; Antineoplastic Agents/pharmacology* ; Artemisia/chemistry ; Artemisinins/chemical synthesis ; Artemisinins/chemistry* ; Artemisinins/pharmacology* ; Carcinoma/drug therapy ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Glycolipids/chemical synthesis ; Glycolipids/chemistry* ; Glycolipids/pharmacology* ; Humans ; Mouth Neoplasms/drug therapy ; Neoplasms/drug therapy
Keywords
artemisinin ; glycolipid ; hybrid ; anti-oral cancer activity
Abstract
Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20 µM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel
Files in This Item:
T201104177.pdf Download
DOI
10.1248/cpb.59.1471
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94655
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