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Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents

Authors
 Jérémy RICCI ; Minkyu KIM ; Mankil JUNG ; Kwang-Kyun PARK ; Won-Yoon CHUNG 
Citation
 Chemical & Pharmaceutical Bulletin, Vol.59(12) : 1471~1475, 2011 
Journal Title
 Chemical & Pharmaceutical Bulletin 
ISSN
 0009-2363 
Issue Date
2011
Abstract
Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20 µM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94655
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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