33 108

Cited 14 times in

Analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study

Authors
 Young-Chul Yoo  ;  Jin Hwan Oh  ;  Sun Joon Bai  ;  Yeong Kyu Lee  ;  Tae Dong Kwon 
Citation
 Yonsei Medical Journal, Vol.52(6) : 1016-1021, 2011 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2011
Abstract
PURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA. RESULTS: In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group. CONCLUSION: The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94509
DOI
10.3349/ymj.2011.52.6.1016
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
권태동(Kweon, Tae Dong) ; 배선준(Bai, Sun Joon) ; 오진환(Oh, Jin Hwan) ; 유영철(Yoo, Young Chul)
사서에게 알리기
  feedback
Files in This Item:
T201103861.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse