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Analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study

Authors
 Young-Chul Yoo  ;  Jin Hwan Oh  ;  Tae Dong Kwon  ;  Yeong Kyu Lee  ;  Sun Joon Bai 
Citation
 YONSEI MEDICAL JOURNAL, Vol.52(6) : 1016-1021, 2011 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2011
MeSH
Acupuncture Analgesia/methods* ; Adrenergic Antagonists/therapeutic use ; Animals ; Arthritis/chemically induced ; Arthritis/drug therapy ; Arthritis/physiopathology ; Arthritis/therapy* ; Carrageenan/toxicity ; Dopamine Antagonists/therapeutic use ; Electroacupuncture/methods* ; Male ; Narcotic Antagonists ; Neurotransmitter Agents/metabolism* ; Pain/drug therapy ; Pain/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic/metabolism ; Receptors, Dopamine/metabolism ; Receptors, Opioid/metabolism ; Receptors, Serotonin/metabolism ; Serotonin Antagonists/therapeutic use
Keywords
Arthritis ; electroacupuncture ; neurotransmitter ; pain ; weight-bearing
Abstract
PURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats.

MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA.

RESULTS: In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group.

CONCLUSION: The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.
Files in This Item:
T201103861.pdf Download
DOI
10.3349/ymj.2011.52.6.1016
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Oh, Jin Hwan(오진환)
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94509
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