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Analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study

DC Field Value Language
dc.contributor.author권태동-
dc.contributor.author배선준-
dc.contributor.author오진환-
dc.contributor.author유영철-
dc.date.accessioned2014-12-20T17:23:20Z-
dc.date.available2014-12-20T17:23:20Z-
dc.date.issued2011-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94509-
dc.description.abstractPURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA. RESULTS: In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group. CONCLUSION: The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1016~1021-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcupuncture Analgesia/methods*-
dc.subject.MESHAdrenergic Antagonists/therapeutic use-
dc.subject.MESHAnimals-
dc.subject.MESHArthritis/chemically induced-
dc.subject.MESHArthritis/drug therapy-
dc.subject.MESHArthritis/physiopathology-
dc.subject.MESHArthritis/therapy*-
dc.subject.MESHCarrageenan/toxicity-
dc.subject.MESHDopamine Antagonists/therapeutic use-
dc.subject.MESHElectroacupuncture/methods*-
dc.subject.MESHMale-
dc.subject.MESHNarcotic Antagonists-
dc.subject.MESHNeurotransmitter Agents/metabolism*-
dc.subject.MESHPain/drug therapy-
dc.subject.MESHPain/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, Adrenergic/metabolism-
dc.subject.MESHReceptors, Dopamine/metabolism-
dc.subject.MESHReceptors, Opioid/metabolism-
dc.subject.MESHReceptors, Serotonin/metabolism-
dc.subject.MESHSerotonin Antagonists/therapeutic use-
dc.titleAnalgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorYoung-Chul Yoo-
dc.contributor.googleauthorJin Hwan Oh-
dc.contributor.googleauthorTae Dong Kwon-
dc.contributor.googleauthorYeong Kyu Lee-
dc.contributor.googleauthorSun Joon Bai-
dc.identifier.doi10.3349/ymj.2011.52.6.1016-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00255-
dc.contributor.localIdA01795-
dc.contributor.localIdA02403-
dc.contributor.localIdA02484-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid22028168-
dc.subject.keywordArthritis-
dc.subject.keywordelectroacupuncture-
dc.subject.keywordneurotransmitter-
dc.subject.keywordpain-
dc.subject.keywordweight-bearing-
dc.contributor.alternativeNameKweon, Tae Dong-
dc.contributor.alternativeNameBai, Sun Joon-
dc.contributor.alternativeNameOh, Jin Hwan-
dc.contributor.alternativeNameYoo, Young Chul-
dc.contributor.affiliatedAuthorKweon, Tae Dong-
dc.contributor.affiliatedAuthorBai, Sun Joon-
dc.contributor.affiliatedAuthorOh, Jin Hwan-
dc.contributor.affiliatedAuthorYoo, Young Chul-
dc.rights.accessRightsfree-
dc.citation.volume52-
dc.citation.number6-
dc.citation.startPage1016-
dc.citation.endPage1021-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.52(6) : 1016-1021, 2011-
dc.identifier.rimsid27376-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
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