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Adjuvant hepatic arterial infusional chemotherapy with 5-fluorouracil and cisplatin after curative resection of hepatocellular carcinoma

Authors
 Kim D.Y.  ;  Ahn S.H.  ;  Kim K.S  ;  Han K.-H.  ;  Lee D.Y.  ;  Park J.Y.  ;  Park M.S.  ;  Lee K.-H.  ;  Choi S.B.  ;  Kim S.U. 
Citation
 Oncology, Vol.81(3-4) : 184-191, 2011 
Journal Title
 Oncology 
ISSN
 0030-2414 
Issue Date
2011
Abstract
OBJECTIVES: We investigated whether adjuvant hepatic arterial infusional chemotherapy (HAIC) with 5-fluorouracil (5-FU) and cisplatin reduces the recurrence of hepatocellular carcinoma (HCC) after curative resection. METHODS: Between January 2006 and December 2008, 31 HCC patients received four cycles of adjuvant HAIC with 5-FU and cisplatin via port system after curative resection. During the same period, 62 patients, who did not take any adjuvant therapy, were selected as controls. RESULTS: Tumor characteristics, such as distribution of TNM stage, pathologic differentiation, portal vein invasion, or microscopic invasion did not differ between control and adjuvant groups. During follow-up, recurrence developed in 11 adjuvant (35.5%) and 24 control patients (38.7%; p = 0.823). Tumor progression after recurrence was the cause of death in 2 adjuvant (28.6%) and 7 control patients (38.8%; p = 0.912). The 2-year recurrence rate was 9.1% in the adjuvant group and 4.2% in the control group, with the median recurrence-free survival time being 10.5 and 7.5 months, respectively (p = 0.324). The 3-year cumulative survival rate was 73.3% in the adjuvant group and 68.3% in the control group (p = 0.355). CONCLUSION: Adjuvant HAIC with 5-FU and cisplatin did not offer any beneficial effect on the recurrence after curative resection of HCC
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94482
DOI
10.1159/000333827
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김경식(Kim, Kyung Sik) ; 김도영(Kim, Do Young) ; 김승업(Kim, Seung Up) ; 박미숙(Park, Mi Sook) ; 박준용(Park, Jun Yong) ; 안상훈(Ahn, Sang Hoon) ; 이광훈(Lee, Kwang Hun) ; 이도연(Lee, Do Yun) ; 한광협(Han, Kwang Hyup)
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http://www.karger.com/Article/FullText/333827
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