287 539

Cited 127 times in

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

Authors
 Jieun Choi  ;  Hyun Jin Min  ;  Jeon-Soo Shin 
Citation
 JOURNAL OF NEUROINFLAMMATION, Vol.8 : 135, 2011 
Journal Title
JOURNAL OF NEUROINFLAMMATION
Issue Date
2011
MeSH
C-Reactive Protein/metabolism ; Child ; Child, Preschool ; Cytokines/blood* ; Cytokines/immunology ; Female ; HMGB1 Protein/blood* ; Humans ; Inflammation/blood* ; Inflammation/immunology* ; Male ; Seizures, Febrile/blood* ; Seizures, Febrile/immunology*
Keywords
Status Epilepticus ; Febrile Seizure ; Intractable Epilepsy ; HMGB1 Level ; Seizure Group
Abstract
OBJECTIVE: Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and pro-inflammatory cytokines, occurs in children with febrile seizures or epilepsy, we analyzed cytokine profiles of patients with febrile seizures or epilepsy.

METHODS: Forty-one febrile seizure patients who visited the emergency department of Seoul National University Boramae Hospital from June 2008 to May 2009 were included in this study. Blood was obtained from the febrile seizure child patients within 30 minutes of the time of the seizure; subsequently, serum cytokine assays were performed. Control samples were collected from children with febrile illness without convulsion (N = 41) and similarly analyzed. Serum samples from afebrile status epilepticus attacks in intractable epilepsy children (N = 12), afebrile seizure attacks in generalized epilepsy with febrile seizure plus (GEFSP) children (N = 6), and afebrile non-epileptic controls (N = 7) were also analyzed.

RESULTS: Serum HMGB1 and IL-1β levels were significantly higher in febrile seizure patients than in fever only controls (p < 0.05). Serum IL-6 levels were significantly higher in typical febrile seizures than in fever only controls (p < 0.05). Serum IL-1β levels were significantly higher in status epilepticus attacks in intractable epilepsy patients than in fever only controls (p < 0.05). Serum levels of IL-1β were significantly correlated with levels of HMGB1, IL-6, and TNF-α (p < 0.05).

CONCLUSIONS: HMGB1 and pro-inflammatory cytokines were significantly higher in febrile seizure children. Although it is not possible to infer causality from descriptive human studies, our data suggest that HMGB1 and the cytokine network may contribute to the generation of febrile seizures in children. There may be a potential role for anti-inflammatory therapy targeting cytokines and HMGB1 in preventing or limiting febrile seizures or subsequent epileptogenesis in the vulnerable, developing nervous system of children
Files in This Item:
T201103744.pdf Download
DOI
10.1186/1742-2094-8-135
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Min, Hyun Jin(민현진)
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94462
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links