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Comparison of gadoxetic acid-enhanced dynamic imaging and diffusion-weighted imaging for the preoperative evaluation of colorectal liver metastases.

Authors
 Woo-Suk Chung  ;  Myeong-Jin Kim  ;  Yong Eun Chung  ;  Yeo-Eun Kim  ;  Mi-Suk Park  ;  Jin-Young Choi  ;  Ki Whang Kim 
Citation
 JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.34(2) : 345-353, 2011 
Journal Title
JOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN
 1053-1807 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; ColorectalNeoplasms/diagnosis* ; ColorectalNeoplasms/pathology* ; Contrast Media/pharmacology ; Diffusion Magnetic ResonanceImaging/methods* ; Female ; Gadolinium DTPA/pharmacology* ; Humans ; LiverNeoplasms/pathology* ; LiverNeoplasms/secondary* ; Male ; Middle Aged ; Neoplasm Metastasis ; Predictive Value of Tests ; ROC Curve ; Reproducibility of Results
Keywords
colorectal ; diffusion‐weighted imaging ; gadoxetic acid ; liver metastases ; MR imaging
Abstract
PURPOSE: To retrospectively compare the diagnostic accuracy for the detection of colorectal liver metastases between gadoxetic acid-enhanced MRI (EOB-MRI) and diffusion-weighted imaging (DWI) on 3.0 Tesla (T) system, and then to determine whether a combination of the two techniques may improve the diagnostic performance.

MATERIALS AND METHODS: Forty-seven patients underwent MR imaging at 3.0T, including DWI (DWI set) and dynamic and hepatobiliary phase EOB-MRI (EOB set) for the preoperative evaluation of colorectal liver metastases. All suspicious metastases were confirmed by hepatic surgery. Two blinded readers independently reviewed three different image sets, which consisted of DWI set, EOB set, and combined set. The accuracy was assessed by the area (Az) under the alternative-free response receiver operating characteristic curve, and the sensitivity and positive predictive value (PPV) were calculated.

RESULTS: We found a total of 78 confirmed colorectal liver metastases in 42 of 47 patients. Each reader noted higher diagnostic accuracy of combined set of EOB-MRI and DWI than DWI set and EOB set, without statistical significance. Regardless of the size of colorectal liver metastasis, each reader detected significantly more metastases on combined set than on DWI set, and PPV was significantly higher with DWI set than with EOB set or with combined set for one reader.

CONCLUSION: EOB-MRI was more useful for the detection of colorectal liver metastases, while DWI was more useful for their characterization. The combination of EOB-MRI and DWI showed significantly higher accuracy and sensitivity for the preoperative detection of small colorectal liver metastases than DWI.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmri.22671/abstract
DOI
10.1002/jmri.22671
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Yeo Eun(김여은)
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Chung, Woo Seok(정우석)
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94296
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