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A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery.

Authors
 Bo Reum Lee  ;  Kyung Taek Oh  ;  Young Taik Oh  ;  Hye Jung Baik  ;  So Young Park  ;  Yu Seok Youn  ;  Eun Seong Lee 
Citation
 CHEMICAL COMMUNICATIONS, Vol.47(13) : 3852-3854, 2011 
Journal Title
CHEMICAL COMMUNICATIONS
ISSN
 1359-7345 
Issue Date
2011
MeSH
Animals ; Antineoplastic Agents/administration & dosage* ; Antineoplastic Agents/therapeutic use ; Chitosan/chemistry* ; Drug Carriers/chemistry* ; Female ; Humans ; Hydrogen-Ion Concentration ; Maleates/chemistry* ; Melanoma, Experimental/drug therapy ; Mice ; Neoplasms/drug therapy* ; Peptides/administration & dosage* ; Peptides/therapeutic use
Abstract
We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.
Full Text
http://pubs.rsc.org/en/Content/ArticleLanding/2011/CC/c0cc03590d
DOI
10.1039/c0cc03590d
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94259
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