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Reproductive risk factors for cardiovascular disease mortality among postmenopausal women in Korea: the Kangwha Cohort Study, 1985-2005.

Authors
 Hoo Sun Chang  ;  Nemekhee Odongua  ;  Heechoul Ohrr  ;  Jae Woong Sull  ;  Chung Mo Nam 
Citation
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.18(11) : 1205-1212, 2011 
Journal Title
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
ISSN
 1072-3714 
Issue Date
2011
MeSH
AgeFactors ; Aged ; CardiovascularDiseases/mortality* ; CohortStudies ; CoronaryDisease/mortality ; Female ; Gravidity ; Humans ; Maternal Age* ; Menarche ; Parity ; Postmenopause ; Pregnancy ; Proportional Hazards Models ; ReproductivePhysiological Phenomena* ; Republic ofKorea/epidemiology ; RiskFactors
Keywords
Cardiovascular disease ; Childbirth ; Coronary heart disease ; Menarche ; Menopause ; Mortality
Abstract
OBJECTIVE: The relationship between reproductive factors and the risk of mortality from cardiovascular disease in postmenopausal women is unclear. In this study, we aimed to investigate this relationship in Korean postmenopausal women.

METHODS: Subcohort analysis was carried out using the data of 3,257 postmenopausal women (age, ≥55 y at study entry) from the Kangwha Cohort Study who were followed up from 1985 until 2005. Cox proportional hazards models were used to evaluate the associations between reproductive factors and cardiovascular disease mortality.

RESULTS: The risk of cardiovascular mortality in women who were 20 to 22 years old at first childbirth was 26% lower (95% CI, 0.60-0.92) than that in women younger than 20 years at first childbirth, after adjustment for age at entry, body mass index, hypertension, drinking, smoking, education, and occupation. Early first childbirth was associated with increased cardiovascular disease mortality (P trend = 0.036). The risk of coronary heart disease mortality was 51% lower in women who were 17 to 18 years old at menarche (95% CI, 0.25-0.95) than that in women who were younger than 17 years at menarche.

CONCLUSIONS: An inverse relationship between age at first childbirth and the risk of cardiovascular disease mortality exists. In addition, early menarche may be a reproductive risk factor for coronary heart disease mortality.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042192-201111000-00011&LSLINK=80&D=ovft
DOI
10.1097/gme.0b013e31821adb43
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Ohrr, Hee Choul(오희철)
Chang, Hoo Sun(장후선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94188
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