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Hypoxia-induced expression of VEGF in the organotypic spinal cord slice culture

Authors
 Sung Su An  ;  William A. Pennant  ;  Keung Nyun Kim  ;  Do Heum Yoon  ;  So-Jung Gwak  ;  Hyo Jin Kim  ;  Jin Soo Oh  ;  Yoon Ha 
Citation
 Neuroreport, Vol.22(2) : 55-60, 2011 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2011
Abstract
We used the erythropoietin enhancer and Simian virus-40 promoter to create a hypoxia-inducible gene expression system to investigate the effect of vascular endothelial growth factor (VEGF) gene therapy on neuroprotection and neurogenesis in organotypic spinal cord slice culture. The organotypic spinal cord slice culture transfected with pEpo-SV-VEGF expressed the highest amount of VEGF under hypoxic conditions and showed decreased apoptosis and increased proliferation, and evidence of neurogenesis. Our results show that the hypoxia-induced VEGF expression in an organotypic spinal cord slice culture may lead to an optimal treatment for spinal cord injury.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94171
DOI
10.1097/WNR.0b013e3283418b00
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
곽소정(Gwak, So Jung) ; 김긍년(Kim, Keung Nyun) ; 김효진(Kim, Hyo Jin) ; 안성수(An, Sung Su) ; 오진수(Oh, Jin Soo) ; 윤도흠(Yoon, Do Heum) ; 하윤(Ha, Yoon)
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