Cited 5 times in
Hypoxia-induced expression of VEGF in the organotypic spinal cord slice culture
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안성수 | - |
dc.contributor.author | 오진수 | - |
dc.contributor.author | 윤도흠 | - |
dc.contributor.author | 하윤 | - |
dc.contributor.author | 곽소정 | - |
dc.contributor.author | 김긍년 | - |
dc.contributor.author | 김효진 | - |
dc.date.accessioned | 2014-12-20T17:12:49Z | - |
dc.date.available | 2014-12-20T17:12:49Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94171 | - |
dc.description.abstract | We used the erythropoietin enhancer and Simian virus-40 promoter to create a hypoxia-inducible gene expression system to investigate the effect of vascular endothelial growth factor (VEGF) gene therapy on neuroprotection and neurogenesis in organotypic spinal cord slice culture. The organotypic spinal cord slice culture transfected with pEpo-SV-VEGF expressed the highest amount of VEGF under hypoxic conditions and showed decreased apoptosis and increased proliferation, and evidence of neurogenesis. Our results show that the hypoxia-induced VEGF expression in an organotypic spinal cord slice culture may lead to an optimal treatment for spinal cord injury. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 55~60 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Astrocytes/metabolism | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | GeneExpression | - |
dc.subject.MESH | Hypoxia/genetics | - |
dc.subject.MESH | Hypoxia/metabolism* | - |
dc.subject.MESH | Neurons | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | SpinalCord/metabolism* | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/genetics | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/metabolism* | - |
dc.title | Hypoxia-induced expression of VEGF in the organotypic spinal cord slice culture | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Sung Su An | - |
dc.contributor.googleauthor | William A. Pennant | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.contributor.googleauthor | Jin Soo Oh | - |
dc.contributor.googleauthor | Hyo Jin Kim | - |
dc.contributor.googleauthor | So-Jung Gwak | - |
dc.contributor.googleauthor | Do Heum Yoon | - |
dc.contributor.googleauthor | Keung Nyun Kim | - |
dc.identifier.doi | 10.1097/WNR.0b013e3283418b00 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02235 | - |
dc.contributor.localId | A02401 | - |
dc.contributor.localId | A02546 | - |
dc.contributor.localId | A04255 | - |
dc.contributor.localId | A00168 | - |
dc.contributor.localId | A00331 | - |
dc.contributor.localId | A01206 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 21753742 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201101260-00002&LSLINK=80&D=ovft | - |
dc.subject.keyword | gene therapy | - |
dc.subject.keyword | hypoxia-inducible gene expression system | - |
dc.subject.keyword | organotypic spinal cord slice culture | - |
dc.contributor.alternativeName | An, Sung Su | - |
dc.contributor.alternativeName | Oh, Jin Soo | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.alternativeName | Ha, Yoon | - |
dc.contributor.alternativeName | Gwak, So Jung | - |
dc.contributor.alternativeName | Kim, Keung Nyun | - |
dc.contributor.alternativeName | Kim, Hyo Jin | - |
dc.contributor.affiliatedAuthor | An, Sung Su | - |
dc.contributor.affiliatedAuthor | Oh, Jin Soo | - |
dc.contributor.affiliatedAuthor | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | Ha, Yoon | - |
dc.contributor.affiliatedAuthor | Gwak, So Jung | - |
dc.contributor.affiliatedAuthor | Kim, Keung Nyun | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 55 | - |
dc.citation.endPage | 60 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.22(2) : 55-60, 2011 | - |
dc.identifier.rimsid | 27287 | - |
dc.type.rims | ART | - |
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