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Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth

Authors
 Su-Jung Shin ; Woocheol Lee ; Kwang-Shik Bae ; Won-Jun Shon ; Kee-Yeon Kum ; Seung-Ho Baek ; Jae-Il Lee 
Citation
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, Vol.112(4) : 548~554, 2011 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 
ISSN
 1079-2104 
Issue Date
2011
Abstract
OBJECTIVE: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in gingival crevicular fluid (GCF) during root canal treatment (RCT) of nonvital teeth. STUDY DESIGN: Patients scheduled for nonsurgical RCT were prospectively selected; all patients provided informed consent. GCF samples were collected from teeth scheduled for RCT and their contralateral teeth across 3 different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis. RESULTS: Patients' subjective pain levels were significantly related to both MMP-8 and SP levels. MMP-8 and SP levels in GCF were decreased during RCT, and they showed a positive correlation with each other (P < .05). CONCLUSIONS: This study demonstrated that periradicular inflammation of endodontic origin can elevate SP and MMP-8 levels in GCF.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94139
DOI
10.1016/j.tripleo.2011.04.026
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Conservative Dentistry
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1079210411002782
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