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Prognostic effect of stromal lymphocyte infiltration in thymic carcinoma

Authors
 Hyo Sup Shim  ;  Chun Sung Byun  ;  Jin Gu Lee  ;  Kyung Young Chung  ;  Dae Joon Kim  ;  In Kyu Park  ;  Chang Young Lee  ;  Mi Kyung Bae 
Citation
 Lung Cancer, Vol.74(2) : 338-343, 2011 
Journal Title
 Lung Cancer 
ISSN
 0169-5002 
Issue Date
2011
Abstract
BACKGROUND: The purpose of this study was to clarify the relationship between the tumor infiltrating lymphocytes and clinical outcome in patients with thymic carcinoma. METHODS: Tissue specimens from 32 patients who underwent surgical resection for thymic carcinoma were immunohistochemically analyzed for CD4, CD8 and CD20 expression. RESULTS: Tumor-infiltrating lymphocytes were generally more abundant in the stroma. The patients with low CD4+ lymphocytes (p=0.037) and low CD20+ lymphocytes (p=0.045) within tumor stroma showed poor survival. Furthermore, concurrent low levels of CD4+ and CD20+ (p=0.014), CD8+ and CD20+ (p=0.025), and, CD4+, CD8+, and CD20+ (p=0.025) in tumor stroma were significantly associated with poor prognosis when compared to the others group. CONCLUSION: Our results indicate that infiltrating CD4+, CD8+, and CD20+ lymphocytes in cancer stroma may cooperate to suppress cancer progression and their presence together appear to be prognostic factor in thymic carcinoma.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94083
DOI
10.1016/j.lungcan.2011.03.008
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학교실)
Yonsei Authors
김대준(Kim, Dae Joon) ; 박인규(Park, In Kyu) ; 배미경(Bae, Mi Kyung) ; 변천성(Byun, Chun Sung) ; 심효섭(Shim, Hyo Sup) ; 이진구(Lee, Jin Gu) ; 이창영(Lee, Chang Young) ; 정경영(Chung, Kyung Young)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0169500211001693
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