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Risk factors for false-negative results of QuantiFERON-TB Gold In-Tube assay in non-HIV-infected patients with culture-confirmed tuberculosis.

Authors
 Eun Young Kim  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Young Ae Kang 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.70(3) : 324-329, 2011 
Journal Title
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
ISSN
 0732-8893 
Issue Date
2011
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Clinical Laboratory Techniques/methods* ; False Negative Reactions* ; Female ; Hospitals ; Humans ; Immunoassay/methods ; Male ; Middle Aged ; Republic of Korea ; Risk Factors ; Sensitivity and Specificity ; Tuberculosis/diagnosis* ; Young Adult
Keywords
Diagnosis ; False negative ; QuantiFERON-TB Gold In-Tube ; Tuberculosis
Abstract
Limited information is available on the risk factors for false-negative results with the new generation of QuantiFERON-TB Gold In-Tube (QFT-GIT) tests in non-HIV-infected patients with tuberculosis (TB). We sought to identify risk factors for false-negative QFT-GIT results in culture-confirmed TB patients. We reviewed the microbiological, laboratory, radiographic, and clinical data of 362 patients with positive M. tuberculosis cultures who received QFT-GIT tests at a Korean tertiary hospital between September 2006 and March 2010. Of these, 311 (85.9%) had true-positive and 51 (14.1%) had false-negative results. The false-negative group was more likely to have immunosuppressant diseases and lower platelet, protein, and albumin levels than the true-positive group. An immunosuppressive condition was an independent risk factor for false-negative QFT-GIT results in non-HIV-infected patients with active TB (odds ratio, 2.98; 95% confidence interval, 1.38-6.47; P = .006). Careful interpretation of negative QFT-GIT results is thus necessary in immunocompromised patients suspected of having active TB
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889311000940
DOI
10.1016/j.diagmicrobio.2011.02.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Se Kyu(김세규)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Young(김은영) ORCID logo https://orcid.org/0000-0002-3281-5744
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94063
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