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The usefulness of liver stiffness measurement using FibroScan in chronic hepatitis C in South Korea: a multicenter, prospective study

 Seung Up Kim  ;  Hui Won Jang  ;  Jae Youn Cheong  ;  Ja Kyung Kim  ;  Myung Hee Lee  ;  Dong Joon Kim  ;  Jin Mo Yang  ;  Sung Won Cho  ;  Kwan Sik Lee  ;  Eun Hee Choi  ;  Young Nyun Park  ;  Kwang-Hyub Han 
 Journal of Gastroenterology and Hepatology, Vol.26(1) : 171-178, 2011 
Journal Title
 Journal of Gastroenterology and Hepatology 
Issue Date
AIM: We investigated the accuracy of liver stiffness measurement (LSM) in chronic hepatitis C (CHC) in a multicenter, prospective study in South Korea. METHODS: Between June 2005 and July 2009, 91 CHC patients without a previous history of antiviral treatment, clinical evidences of cirrhosis, coinfection with other viruses, and heavy alcohol consumption and with alanine aminotransferase (ALT) ≤5x upper limit of normal, total bilirubin ≤1.5 mg/dL, sufficient liver biopsy quality (≥15 mm and more than six portal tracts), interquartile range to median liver stiffness (LS) value ratio ≤0.21, and more than 10 valid measurements, were recruited. The Batts and Ludwig scoring system was used for histologic assessment. Age-platelet index (API), aspartate aminotransferase (AST)-to-platelet ratio index (APRI), and age-spleen-platelet ratio index (ASPRI) were calculated. Area under the receiver operating characteristic curve (AUROC) was used to evaluate the performance of LSM and other noninvasive models. RESULTS: The mean age was 47.9 years, and the mean LS value was 7.7 kPa (44 men and 47 women). LS value was highly correlated to the fibrosis stages (r=0.835, P<0.001). The AUROCs of LSM were 0.909 for ≥F2, 0.993 for ≥F3, and 0.970 for F=4 and were superior to those of API (0.72, 0.858, and 0.948, respectively), APRI (0.780, 0.887, and 0.904, respectively), and ASPRI (0.713, 0.862, and 0.957, respectively). The optimal cutoff LS values were 6.2 kPa for ≥F2, 7.7 kPa for ≥F3, and 11.0 kPa for F=4. CONCLUSIONS: Our data suggest that LSM can accurately assess liver fibrosis in patients with CHC and be applied in South Korea.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김승업(Kim, Seung Up) ; 김자경(Kim, Ja Kyung) ; 박영년(Park, Young Nyun) ; 이관식(Lee, Kwan Sik) ; 장희원(Jang, Hui Won) ; 최은희(Choi, Eun Hee) ; 한광협(Han, Kwang Hyup)
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