1 140

Cited 0 times in

Effects of HB-EGF and epiregulin on wound healing of gingival cells in vitro.

Authors
 JM Kim  ;  EJ Bak  ;  JY Chang  ;  S-T Kim  ;  W-S Park  ;  Y-J Yoo  ;  J-H Cha 
Citation
 Oral Diseases, Vol.17(8) : 785-793, 2011 
Journal Title
 Oral Diseases 
ISSN
 1354-523X 
Issue Date
2011
Abstract
OBJECTIVE: Gingival wound healing is important to periodontal disease and surgery. This in vitro study was conducted to assess the manner in which heparin-binding epidermal growth factor-like growth factor (HB-EGF) and epiregulin cooperatively participate in the wound-healing process in the gingival epithelial and fibroblast cells of the oral mucosa. MATERIAL AND METHODS: Gingival epithelium and fibroblast were separated from gingival tissue biopsies and prepared to primary cultures. The changes in the mRNA expression were evaluated via real-time PCR. The effects on cell proliferation, migration, and repopulation were evaluated in vitro. RESULTS: The different regulation of expressions of HB-EGF, epiregulin, and epidermal growth factor receptors was observed over time and with different gingival cell types. HB-EGF exerted a cell migration-inducing effect on both epithelial and fibroblast cells, whereas epiregulin did not. Both growth factors functioned as mitogens for epithelial cell proliferation, but not for fibroblast proliferation. HB-EGF strongly promoted epithelial cell repopulation and mildly promoted fibroblast repopulation, whereas epiregulin promoted only fibroblast repopulation. CONCLUSION: These results indicated that both growth factors might function importantly in the wound-healing process of human gingival tissue via the different regulation of the expression, cell migration, proliferation, and repopulation.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93909
DOI
10.1111/j.1601-0825.2011.01836.x
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
Yonsei Authors
김성태(Kim, Sung Tae) ; 김진문(Kim, Jin Moon) ; 박원서(Park, Wonse) ; 박은정(Bak, Eun-Jung) ; 유윤정(Yoo, Yun Jung) ; 차정헌(Cha, Jung Heon)
사서에게 알리기
  feedback
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01836.x/abstract;jsessionid=A26F69BD8958EC9EDCDD2B436F074799.f01t01
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse