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Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma

Authors
 Kyung Won Kim  ;  Kyung Eun Lee  ;  Jung Yeon Hong  ;  Mi Na Kim  ;  Won Il Heo  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
Citation
 Lung, Vol.189(5) : 417-423, 2011 
Journal Title
 Lung 
ISSN
 0341-2040 
Issue Date
2011
Abstract
Asthma and atopy have a complex background that may result from the interaction of genes and the environment. Interleukin (IL)-10 is known to play various roles in immune-regulating and anti-inflammatory responses. The aim of this study was to evaluate the possible effect of the IL-10 promoter polymorphisms on susceptibility to childhood asthma. We recruited 333 patients with atopic asthma, 55 with nonatopic asthma, and 248 normal controls. We performed a genetic association study of three genetic polymorphisms (IL-10 -1082A>G, IL-10 -819T>C, and IL-10 -592A>C) of the IL-10 promoter. There was no difference between atopic asthma, nonatopic asthma, and normal controls with respect to allele, genotype, or haplotype frequencies of these IL-10 polymorphisms. However, the -1082A>G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) and the -819T>C, -592A>C, and ATA and ACC haplotypes were also shown to be related to serum eosinophil cationic protein (ECP). Our results suggest that the polymorphisms within the IL-10 promoter may have a disease-modifying effect in the asthmatic airway.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93715
DOI
10.1007/s00408-011-9312-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김경원(Kim, Kyung Won) ; 김규언(Kim, Kyu Earn) ; 김미나(Kim, Mina) ; 손명현(Sohn, Myung Hyun) ; 허원일(Heo, Won Il) ; 홍정연(Hong, Jung Yeon)
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Full Text
http://link.springer.com/article/10.1007%2Fs00408-011-9312-5
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